Journal article
Supplementary Oxygen Efficacy for Chronic Pulmonary Disorders and Exertion Desaturation
ERJ open research, Vol.10(6), 00411-2024
11/2024
DOI: 10.1183/23120541.00411-2024
PMCID: PMC11626617
PMID: 39655174
Abstract
Introduction Exertion-Induced Desaturation (EID) is a common complication of numerous pulmonary disorders and often treated with supplementary oxygen during exertion. We performed a systematic review and meta-analysis of Randomized Clinical Trials (RCTs) to evaluate the efficacy of supplementary oxygen for EID in pulmonary disorders. Material and methods Medline and Embase were systematically searched from July 2022 to June 2023 following PRISMA guidelines. RCTs that met predefined inclusion criteria were included. Means and Standard Deviations were extracted and Standardized Mean Differences (SMD), the difference in means between groups divided by the Standard Deviation, and 95% Confidence Intervals (CI) calculated. Exercise capacity was the primary outcome; exercise dyspnea, baseline dyspnea, quality of life were the secondary objectives. The immediate, post-rehabilitation, short-term, and ambulatory effects of oxygen supplementation were evaluated. Results We included 15 studies in our analysis. Oxygen supplementation to treat EID had been investigated for Chronic Obstructive Pulmonary Disease (COPD) and Interstitial Pulmonary Fibrosis (IPF) only. Oxygen supplementation was superior to placebo for its immediate effect on exercise capacity for COPD (SMD: 0.42, 95% CI: 0.15 to 0.69, I 2 =3%) and IPF (SMD: 0.41, 95% CI: 0.08 to 0.75, I 2 =57%) and exercise dyspnea for COPD (SMD: −0.40, 95% CI: −0.76 to −0.04, I 2 =31%). Sensitivity analysis revealed similar results. Conclusions Our study revealed efficacy of supplemental oxygen for EID and only a positive immediate effect on exercise capacity and dyspnea but no improvement in short-term or long-term measures.
Details
- Title: Subtitle
- Supplementary Oxygen Efficacy for Chronic Pulmonary Disorders and Exertion Desaturation
- Creators
- Paraschos Archontakis BarakakisAdam Wolfe - University of IowaAndrei Schwartz - University of Iowa, Internal MedicineGabriel J. Hernandez RomeroVipul Gidwani - Geisinger Medical CenterShaylika Chauhan - Geisinger Medical CenterShinichi Arizono - Seirei Christopher UniversityRalph J. Panos - University of Cincinnati Medical CenterSpyridon Fortis - Iowa City VA Health Care System
- Resource Type
- Journal article
- Publication Details
- ERJ open research, Vol.10(6), 00411-2024
- DOI
- 10.1183/23120541.00411-2024
- PMID
- 39655174
- PMCID
- PMC11626617
- NLM abbreviation
- ERJ Open Res
- ISSN
- 2312-0541
- eISSN
- 2312-0541
- Publisher
- EUROPEAN RESPIRATORY SOC JOURNALS LTD
- Language
- English
- Electronic publication date
- 08/08/2024
- Date published
- 11/2024
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984696864502771
Metrics
15 Record Views