Journal article
Suppression of Extracellular Signal-Regulated Kinase Activity in Herpes Simplex Virus 1-Infected Cells by the Us3 Protein Kinase
Journal of virology, Vol.86(15), pp.7771-7776
08/2012
DOI: 10.1128/JVI.00622-12
PMCID: PMC3421675
PMID: 22593153
Abstract
Host mitogen-activated protein kinases (MAPKs) are deregulated by herpes simplex virus 1 (HSV-1). Unlike p38 MAPK and Jun N-terminal protein kinase (JNK), which require ICP27 for their activation early in infection, extracellular signal-regulated kinase (ERK) activity is suppressed by an unknown mechanism. Here, we establish that HSV-1-induced suppression of ERK activity requires viral gene expression, occurs with delayed-early kinetics, and requires the functional virus-encoded Us3 Ser/Thr protein kinase. Finally, Us3 expression in uninfected cells was necessary and sufficient to suppress ERK activity in the absence of any other virus-encoded gene products. This demonstrates that inhibition of ERK activity in HSV-1-infected cells is an intrinsic Us3 function and defines a new role for this alphaherpesvirus Us3 kinase in regulating MAPK activation in infected cells.
Details
- Title: Subtitle
- Suppression of Extracellular Signal-Regulated Kinase Activity in Herpes Simplex Virus 1-Infected Cells by the Us3 Protein Kinase
- Creators
- Uyanga Chuluunbaatar - Department of Microbiology and NYU Cancer Institute, New York University School of Medicine, New York, New York, USARichard Roller - Department of Microbiology, University of Iowa, Iowa City, Iowa, USAIan Mohr - Department of Microbiology and NYU Cancer Institute, New York University School of Medicine, New York, New York, USA
- Resource Type
- Journal article
- Publication Details
- Journal of virology, Vol.86(15), pp.7771-7776
- Publisher
- American Society for Microbiology; 1752 N St., N.W., Washington, DC
- DOI
- 10.1128/JVI.00622-12
- PMID
- 22593153
- PMCID
- PMC3421675
- ISSN
- 0022-538X
- eISSN
- 1098-5514
- Language
- English
- Date published
- 08/2012
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001142402771
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