Journal article
Suppression of evoked IPSPs by arachidonic acid and prostaglandin F 2α
Brain research, Vol.691(1), pp.223-228
1995
DOI: 10.1016/0006-8993(95)00405-F
Abstract
Arachidonic acid (AA) and certain prostagladins appear to antagonize GABA
A receptors in synaptoneurosomes [18]. We report here that perfusing hippocampal slices with AA or prstaglandin F
2α diminishes evoked IPSP conductance and increases CA1 pyramidal cell input resistance. The effects of the two compounds were similar, though not identical, in time course, magnitude, and response to washout. These findings suggest that high levels of AA and its metabolites may bias neurons towards excitation.
Details
- Title: Subtitle
- Suppression of evoked IPSPs by arachidonic acid and prostaglandin F 2α
- Creators
- James Owens - University of Iowa, Stead Family Department of PediatricsPhilip A. Schwartzkroin - University of Washington
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.691(1), pp.223-228
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(95)00405-F
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Grant note
- NINDS NIH HHS: NS15317
- Language
- English
- Date published
- 1995
- Academic Unit
- Neurology (Pediatrics); Stead Family Department of Pediatrics
- Record Identifier
- 9984701553002771
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