Journal article
Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status
International Journal of Bipolar Disorders, Vol.11(1), 32
10/01/2023
DOI: 10.1186/s40345-023-00312-9
PMCID: PMC10542629
PMID: 37779127
Abstract
Background
Widely reported by bipolar disorder (BD) patients, cognitive symptoms, including deficits in executive function, memory, attention, and timing are under-studied. Work suggests that individuals with BD show impairments in interval timing tasks, including supra-second, sub-second, and implicit motor timing compared to the neuronormative population. However, how time perception differs within individuals with BD based on disorder sub-type (BDI vs II), depressed mood, or antipsychotic medication-use has not been thoroughly investigated. The present work administered a supra-second interval timing task concurrent with electroencephalography (EEG) to patients with BD and a neuronormative comparison group. As this task is known to elicit frontal theta oscillations, signal from the frontal (Fz) lead was analyzed at rest and during the task.
Results
Results suggest that individuals with BD show impairments in supra-second interval timing and reduced frontal theta power during the task compared to neuronormative controls. However, within BD sub-groups, neither time perception nor frontal theta differed in accordance with BD sub-type, depressed mood, or antipsychotic medication use.
Conclusions
This work suggests that BD sub-type, depressed mood status or antipsychotic medication use does not alter timing profile or frontal theta activity. Together with previous work, these findings point to timing impairments in BD patients across a wide range of modalities and durations indicating that an altered ability to assess the passage of time may be a fundamental cognitive abnormality in BD.
Details
- Title: Subtitle
- Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status
- Creators
- Victória A Müller Ewald - St. Mary's College of MarylandNicholas T. Trapp - University of IowaMcCall E. Sarrett - Gonzaga UniversityBenjamin D. Pace - University of IowaLinder Wendt - University of IowaJenny G. Richards - University of IowaIlisa K. Gala - University of IowaJacob N. Miller - St. Luke’s HospitalJan R. Wessel - University of IowaVincent A. Magnotta - University of IowaJohn A. Wemmie - University of IowaAaron D. Boes - University of IowaKrystal L. Parker - University of Iowa
- Resource Type
- Journal article
- Publication Details
- International Journal of Bipolar Disorders, Vol.11(1), 32
- DOI
- 10.1186/s40345-023-00312-9
- PMID
- 37779127
- PMCID
- PMC10542629
- NLM abbreviation
- Int J Bipolar Disord
- ISSN
- 2194-7511
- eISSN
- 2194-7511
- Publisher
- Springer Berlin Heidelberg
- Grant note
- Baszucki Brain Research Fund R01MH113325 / NIMH R01DA052953 / National Institute on Drug Abuse (http://dx.doi.org/10.13039/100000026) Merit Review Award / U.S. Department of Veterans Affairs (http://dx.doi.org/10.13039/100000738) Bipolar Disorder Research Program of Excellence - University of Iowa Roy J. Carver Charitable Trust
- Language
- English
- Date published
- 10/01/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Molecular Physiology and Biophysics; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurology (Pediatrics); Neurosurgery
- Record Identifier
- 9984473759102771
Metrics
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