Supraventricular tachyarrhythmias after hematopoietic stem cell transplantation : incidence, risk factors and outcomes

M TOMASSON; J. D HIDALGO; R KRONE; L. T GOODNOUGH; R VIJ; J DIPERSIO; H KHOURY; M. W RICH; K BLUM; D ADKINS; M-Y FAN; R BROWN; S DEVINE; T GRAUBERT; W BLUM

doi:10.1038/sj.bmt.1704623

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Supraventricular tachyarrhythmias after hematopoietic stem cell transplantation : incidence, risk factors and outcomes

Journal article

Peer reviewed

Supraventricular tachyarrhythmias after hematopoietic stem cell transplantation : incidence, risk factors and outcomes

M TOMASSON, J. D HIDALGO, R KRONE, L. T GOODNOUGH, R VIJ, J DIPERSIO, H KHOURY, M. W RICH, K BLUM, D ADKINS, …

Bone marrow transplantation (Basingstoke), Vol.34(7), pp.615-619

2004

DOI: 10.1038/sj.bmt.1704623

PMID: 15258562

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Abstract

Recent studies suggest that cancer patients may be at increased risk for supraventricular tachyarrhythmias (SVTA). We have observed clinically significant SVTA in patients undergoing hematopoietic stem cell transplantation occurring at a median of 6 days post transplant, manifesting as atrial fibrillation/flutter or regular narrow-complex tachycardia and persisting for a median of 3 days (range, 0-8). All patients received aggressive medical therapy and/or electrical cardioversion to restore sinus rhythm and to re-establish hemodynamic stability. Non-Hodgkin's lymphoma (NHL) was the most common diagnosis (53%), and a case control analysis in those patients demonstrated that SVTA occurred in 12% of patients and was associated with older age and pre-existing cardiac conditions. In conclusion, patients undergoing HSCT are at moderate risk for developing SVTA, particularly older patients with a diagnosis of NHL. These arrhythmias are clinically significant, and are a marker for increased mortality and prolonged hospital stay. Additional studies are needed to identify high-risk patients who may benefit from prophylactic anti-arrhythmic therapy.

Biological and medical sciences

Medical sciences

Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy

Bone marrow, stem cells transplantation. Graft versus host reaction

Transfusions. Complications. Transfusion reactions. Cell and gene therapy

Details

Title: Subtitle: Supraventricular tachyarrhythmias after hematopoietic stem cell transplantation : incidence, risk factors and outcomes
Creators: M TOMASSON - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
J. D HIDALGO - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
R KRONE - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
L. T GOODNOUGH - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
R VIJ - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
J DIPERSIO - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
H KHOURY - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
M. W RICH - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
K BLUM - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
D ADKINS - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
M-Y FAN - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
R BROWN - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
S DEVINE - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
T GRAUBERT - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
W BLUM - Division of Oncology, Section of BMT and Leukemia, and Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States
Resource Type: Journal article
Publication Details: Bone marrow transplantation (Basingstoke), Vol.34(7), pp.615-619
DOI: 10.1038/sj.bmt.1704623
PMID: 15258562
NLM abbreviation: Bone Marrow Transplant
ISSN: 0268-3369
eISSN: 1476-5365
Publisher: Nature Publishing Group
Language: English
Date published: 2004
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984094655302771

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