Surfactant and patent ductus arteriosus

Abhay Kumar; Anil Lakkundi; Patrick J McNamara; Arvind Sehgal

doi:10.1007/s12098-009-0299-3

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Journal article

Peer reviewed

Surfactant and patent ductus arteriosus

Abhay Kumar, Anil Lakkundi, Patrick J McNamara and Arvind Sehgal

Indian journal of pediatrics, Vol.77(1), pp.51-55

01/2010

DOI: 10.1007/s12098-009-0299-3

PMID: 20091373

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Abstract

To investigate the relationship between surfactant replacement therapy and the development of a haemodynamically significant ductus arteriosus. All premature infants at 28-32 wk gestation with a clinical diagnosis of respiratory distress syndrome were retrospectively reviewed and subdivided into two groups; intubated, mechanically ventilated and received surfactant (Group 1); and received nasal continuous positive airway pressure alone (Group 2). The relationship between groups and characteristics of the hemodynamically significant ductus arteriosus was analyzed. Seventy babies were identified of whom 35 (50%) received surfactant. Babies in group I and II were comparable for gestational age, birthweight, antenatal steroids, gender and fluid intake in first week of life. Babies treated with surfactant therapy were found to be more likely to have a haemodynamically significant ductus arteriosus (p<0.01), larger transductal diameter (p=0.01) and increased rate of therapeutic interventions to close the ductus (p<0.01). Ventilation parameters (mean airway pressure and fractional inspired oxygen) were higher in group I. Neonates with respiratory distress syndrome (RDS) who were treated with surfactant replacement are at increased risk of a hemodynamically significant ductus arteriosus that requires therapeutic intervention. Whether the relationship reflects their underlying lung disease or is a direct effect of surfactant requires prospective evaluation.

Respiratory Distress Syndrome, Newborn - therapy

Continuous Positive Airway Pressure - methods

Surface-Active Agents - therapeutic use

Ductus Arteriosus, Patent - epidemiology

Humans

Infant, Premature

Respiratory Distress Syndrome, Newborn - epidemiology

Retrospective Studies

Respiratory Distress Syndrome, Newborn - drug therapy

Gestational Age

Infant, Newborn

Details

Title: Subtitle: Surfactant and patent ductus arteriosus
Creators: Abhay Kumar - Monash Newborn Monash, Medical Centre, Clayton, VIC, Australia
Anil Lakkundi
Patrick J McNamara
Arvind Sehgal
Resource Type: Journal article
Publication Details: Indian journal of pediatrics, Vol.77(1), pp.51-55
DOI: 10.1007/s12098-009-0299-3
PMID: 20091373
ISSN: 0019-5456
eISSN: 0973-7693
Language: English
Date published: 01/2010
Academic Unit: Stead Family Department of Pediatrics; Neonatology; Internal Medicine
Record Identifier: 9984093487602771

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