Journal article
Surgical Management of Neuroendocrine Tumor Liver Metastases
Surgical oncology clinics of North America, Vol.30(1), pp.39-55
01/01/2021
DOI: 10.1016/j.soc.2020.08.001
PMCID: PMC7739028
PMID: 33220808
Abstract
Patients with neuroendocrine tumor liver metastases (NETLMs) may develop carcinoid syndrome, carcinoid heart disease, or other symptoms from overproduction of hormones. Hepatic resection and cytoreduction is the most direct treatment of NETLMs in eligible patients, and cytoreduction improves symptoms, may reduce the sequelae of carcinoid syndrome, and extends survival. Parenchymal-sparing procedures, such as ablation and enucleation, should be considered during cytoreduction to maximize treatment of multifocal tumors while preserving healthy liver tissue. For patients with large hepatic tumor burdens, high-grade disease, or comorbidities precluding surgery, liver-directed and systemic therapies can be used to palliate symptoms and improve progression-free survival.
Details
- Title: Subtitle
- Surgical Management of Neuroendocrine Tumor Liver Metastases
- Creators
- Catherine G. Tran - University of IowaScott K. Sherman - Roy J. and Lucille A. Carver College of MedicineChandrikha Chandrasekharan - University of IowaJames R. Howe - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Surgical oncology clinics of North America, Vol.30(1), pp.39-55
- DOI
- 10.1016/j.soc.2020.08.001
- PMID
- 33220808
- PMCID
- PMC7739028
- NLM abbreviation
- Surg Oncol Clin N Am
- ISSN
- 1055-3207
- eISSN
- 1558-5042
- Publisher
- Elsevier
- Number of pages
- 17
- Grant note
- P50 CA174521-01 / Specialized Programs of Research Excellence T32CA148062; T32CA078586 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 01/01/2021
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Surgery; Internal Medicine
- Record Identifier
- 9984322810002771
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