Journal article
Surgical Management of Neuroendocrine Tumor Liver Metastases
Hematology/oncology clinics of North America, Vol.39(1), pp.37-53
02/2025
DOI: 10.1016/j.hoc.2024.08.001
PMID: 39510676
Abstract
Patients with neuroendocrine tumor liver metastases (NETLMs) may develop carcinoid syndrome, carcinoid heart disease, or other symptoms from overproduction of hormones. Hepatic resection and cytoreduction is the most direct treatment of NETLMs in eligible patients, and cytoreduction improves symptoms, may reduce the sequelae of carcinoid syndrome, and extends survival. Parenchymal-sparing procedures, such as ablation and enucleation, should be considered during cytoreduction to maximize treatment of multifocal tumors while preserving healthy liver tissue. For patients with large hepatic tumor burdens, high-grade disease, or comorbidities precluding surgery, liver-directed and systemic therapies can be used to palliate symptoms and improve progression-free survival.
Details
- Title: Subtitle
- Surgical Management of Neuroendocrine Tumor Liver Metastases
- Creators
- Catherine G. Tran - University of MinnesotaScott K. Sherman - University of IowaChandrikha Chandrasekharan - Division of Hematology Oncology, MD Anderson Cancer Center, Houston, TXJames R. Howe - Department of Surgery, Division of Surgical Oncology and Endocrine Surgery, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Hematology/oncology clinics of North America, Vol.39(1), pp.37-53
- DOI
- 10.1016/j.hoc.2024.08.001
- PMID
- 39510676
- NLM abbreviation
- Hematol Oncol Clin North Am
- ISSN
- 0889-8588
- eISSN
- 1558-1977
- Publisher
- Elsevier Inc
- Number of pages
- 17
- Grant note
- NIH: T32CA148062, T32CA078586 Specialized Programs of Research Excellence: P50 CA174521-01
This work was supported by NIH grants no. T32CA148062 (C.G. Tran) , T32CA078586 (S.K. Sherman) , and Specialized Programs of Research Excellence grant no. P50 CA174521-01 (J.R. Howe) .
- Language
- English
- Date published
- 02/2025
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Surgery; Internal Medicine
- Record Identifier
- 9984742657002771
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