Journal article
Surgical Stress Promotes Tumor Growth in Ovarian Carcinoma
Clinical cancer research, Vol.15(8), pp.2695-2702
04/15/2009
DOI: 10.1158/1078-0432.CCR-08-2966
PMCID: PMC2746852
PMID: 19351748
Abstract
Surgical stress has been suggested to facilitate the growth of pre-existing micrometastases as well as small residual tumor postoperatively. The purpose of this study was to examine the effects of surgical stress following either mastectomy or laparotomy on ovarian cancer growth and to determine underlying mechanisms responsible for increased growth. In both HeyA8 and SKOV3ip1 models, the mice in the laparotomy and mastectomy groups had significantly greater tumor weight (
P
< 0.05) and nodules (
P
< 0.05) compared to anesthesia only controls. There was no increase in tumor weight following surgery in the β-adrenergic receptor (ADRB)-negative RMG-II model. To block the influence of sympathetic nervous system activation by surgical stress, we used propranolol infusion via Alzet pumps. Propranolol completely blocked the effects of surgical stress on tumor growth, indicating a critical role for ADRB signaling in mediating the effects of surgical stress on tumor growth. In the HeyA8 and SKOV3ip1 models, surgery significantly increased microvessel density (CD31) and VEGF expression, which were blocked by propranolol treatment. These results indicate that surgical stress could enhance tumor growth and angiogenesis, and β-blockade might be effective in preventing such effects.
Details
- Title: Subtitle
- Surgical Stress Promotes Tumor Growth in Ovarian Carcinoma
- Creators
- Jeong-Won Lee - Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030Mian M.K Shahzad - Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030Yvonne G Lin - Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030Guillermo Armaiz-Pena - Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030Hee-Dong Han - Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030Hye-Sun Kim - Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030Eun Ji Nam - Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030Nicholas B Jennings - Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030Jyotsnabaran Halder - Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030Lingegowda S Mangala - Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030Alpa M Nick - Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030Rebecca L Stone - Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030Chunhua Lu - Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030Susan K Lutgendorf - Department of Psychology, University of Iowa, Iowa City, Iowa 52241Steven W Cole - Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, CA 90095Anna E Lokshin - Department of Medicine and Pathology, University of Pittsburgh, Pittsburgh, PA 15261Anil K Sood - Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030
- Resource Type
- Journal article
- Publication Details
- Clinical cancer research, Vol.15(8), pp.2695-2702
- DOI
- 10.1158/1078-0432.CCR-08-2966
- PMID
- 19351748
- PMCID
- PMC2746852
- NLM abbreviation
- Clin Cancer Res
- ISSN
- 1078-0432
- eISSN
- 1557-3265
- Language
- English
- Date published
- 04/15/2009
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984065883702771
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