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Surgical management of a case of severe leukemic retinopathy
Journal article   Open access   Peer reviewed

Surgical management of a case of severe leukemic retinopathy

Farzad Jamshidi, Timothy M. Boyce, R Christopher Bowen, H Culver Boldt and Elaine M. Binkley
American journal of ophthalmology case reports, Vol.39, 102417
09/01/2025
DOI: 10.1016/j.ajoc.2025.102417
PMCID: PMC12433482
PMID: 40955320
url
https://doi.org/10.1016/j.ajoc.2025.102417View
Published (Version of record) Open Access

Abstract

Purpose: To present a case of severe leukemic retinopathy requiring surgical rehabilitation. We report four-year follow up and associated post-remission pathology including cystoid macular edema (CME) and retinal ischemia. Observations: This is a case report of a 35-year-old female with acute myelocytic leukemia (AML) who presented with hand motions (HM) vision in both eyes and severe multilayered hemorrhages. She underwent pars plana vitrectomy (PPV) in the left eye and subsequent PPV with internal limiting membrane (ILM) peel in the right eye after autologous bone marrow transplant. After cataract surgery and treatment of CME, visual acuity improved to 20/25 in each eye. Fundus examination and optical coherence tomography (OCT) revealed outer retinal loss outside of the fovea. Conclusions and importance: Surgical intervention can be necessary for visual rehabilitation in some patients with leukemic retinopathy. With improved medical treatment for AML, patients survive longer, making visual rehabilitation more impactful and allowing for a better understanding of the natural history of leukemic retinopathy.
 Leukemia Retinopathy Vitreoretinal surgery

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