Journal article
Surgical management of fibrotic encapsulation of the fluocinolone acetonide implant in CAPN5-associated proliferative vitreoretinopathy
Clinical Ophthalmology, Vol.7, pp.1093-1098
2013
DOI: 10.2147/OPTH.S43939
PMCID: PMC3682853
PMID: 23785231
Abstract
OBJECTIVE: To review fibrosis of fluocinolone acetonide (FA) implants in subjects with CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV).METHODS: A retrospective case series was assembled from ADNIV patients in which there was fibrotic encapsulation of a fluocinolone acetonide implant. CAPN5 genotypes and surgical repair techniques were reviewed.RESULTS: Two eyes of two ADNIV patients developed a fibrotic capsule over the fluocinolone acetonide implant. Both patients had Stage IV disease. Patient A had a c.731T > C mutation in the CAPN5 gene and patient B had a c.728G > T mutation. The fibrotic membrane was surgically excised and the implant function was restored.CONCLUSION: The exuberant fibrotic response in later stages of ADNIV may be resistant to local immunosuppression with steroids. Surgical excision of fibrotic membranes over FA implants can reestablish local steroid delivery in cases of severe proliferative vitreoretinopathy.
Details
- Title: Subtitle
- Surgical management of fibrotic encapsulation of the fluocinolone acetonide implant in CAPN5-associated proliferative vitreoretinopathy
- Creators
- Paul S TlucekJames C FolkVinit B MahajanWarren M Sobol
- Resource Type
- Journal article
- Publication Details
- Clinical Ophthalmology, Vol.7, pp.1093-1098
- DOI
- 10.2147/OPTH.S43939
- PMID
- 23785231
- PMCID
- PMC3682853
- NLM abbreviation
- Clin Ophthalmol
- ISSN
- 1177-5483
- eISSN
- 1177-5483
- Language
- English
- Date published
- 2013
- Academic Unit
- Stead Family Department of Pediatrics; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980061902771
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