Journal article
Surveillance imaging during first remission in follicular lymphoma does not impact overall survival
Cancer, Vol.127(18), pp.3390-3402
09/15/2021
DOI: 10.1002/cncr.33660
PMCID: PMC8800454
PMID: 34157780
Abstract
Background Although many patients with follicular lymphoma (FL) undergo routine radiographic surveillance during their first remission, no consensus exists on the modality, duration, frequency, or need for routine imaging studies. The authors retrospectively examined the effect of surveillance imaging on relapse detection and overall survival (OS) in patients with FL. Methods Patients with newly diagnosed FL who had a response to induction therapy were identified from the Lymphoid Malignancies Enterprise Architecture Database (LEAD) at Emory University and from the Molecular Epidemiology Resource (MER) of the University of Iowa/Mayo Clinic. Patients were evaluated for both relapse and method of relapse detection (ie, clinical concerns vs radiologic detection through surveillance imaging in an asymptomatic patient). Results Of 148 patients in the LEAD cohort, 55 (37%) relapsed, and the majority (n = 35; 64%) of relapses were detected clinically. In the MER cohort, 63 of 177 relapses (54%) were detected clinically. There was no significant difference in OS from the date of diagnosis between the 2 methods of relapse detection in the LEAD (hazard ratio [HR], 0.61; 95% CI, 0.13-2.94; P = .54) and MER (HR, 1.02; 95% CI, 0.47-2.21; P = .96) cohorts. Similarly, there was no significant difference in OS from the date of relapse between the 2 methods of relapse detection in the LEAD (HR, 0.47; 95% CI, 0.10-2.27; P = .35) and MER (HR, 1.02; 95% CI, 0.47-2.21; P = .96) cohorts. Conclusions These findings suggest a limited role for routine surveillance imaging in patients with FL who complete front-line therapy. Future studies should evaluate which patients may benefit from a more aggressive surveillance approach and should explore novel methods of relapse detection.
Details
- Title: Subtitle
- Surveillance imaging during first remission in follicular lymphoma does not impact overall survival
- Creators
- Max L. Goldman - Emory UniversityJimmy J. Mao - Mayo ClinicChristopher S. Strouse - University of IowaWanqi Chen - Emory UniversityManali Rupji - Emory UniversityZhengjia Chen - Emory UniversityMatthew J. Maurer - Mayo ClinicOscar Calzada - Emory UniversityMichael Churnetski - Emory UniversityChristopher R. Flowers - Emory UniversityJames R. Cerhan - Mayo ClinicBrian K. Link - University of IowaCarrie A. Thompson - Mayo ClinicJonathon B. Cohen - Emory University
- Resource Type
- Journal article
- Publication Details
- Cancer, Vol.127(18), pp.3390-3402
- DOI
- 10.1002/cncr.33660
- PMID
- 34157780
- PMCID
- PMC8800454
- NLM abbreviation
- Cancer
- ISSN
- 0008-543X
- eISSN
- 1097-0142
- Publisher
- Wiley
- Number of pages
- 13
- Grant note
- American Society of Hematology Williams Family Foundation of Georgia
- Language
- English
- Date published
- 09/15/2021
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984359773702771
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