Survey of bloodstream infections due to gram-negative bacilli: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, and Latin America for the SENTRY Antimicrobial Surveillance Program, 1997

D J Diekema; M A Pfaller; R N Jones; G V Doern; P L Winokur; A C Gales; H S Sader; K Kugler; M Beach

doi:10.1086/598640

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Survey of bloodstream infections due to gram-negative bacilli: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, and Latin America for the SENTRY Antimicrobial Surveillance Program, 1997

Journal article

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Survey of bloodstream infections due to gram-negative bacilli: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, and Latin America for the SENTRY Antimicrobial Surveillance Program, 1997

D J Diekema, M A Pfaller, R N Jones, G V Doern, P L Winokur, A C Gales, H S Sader, K Kugler and M Beach

Clinical infectious diseases, Vol.29(3), pp.595-607

09/1999

DOI: 10.1086/598640

PMID: 10530454

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Abstract

During 1997, a total of 4,267 nosocomial and community-acquired bloodstream infections due to gram-negative organisms were reported from SENTRY hospitals in Canada (8 sites), the United States (30 sites), and Latin America (10 sites). Escherichia coli was the most common isolate (41% of all gram-negative isolates), followed by Klebsiella species (17.9%), Pseudomonas aeruginosa (10.6%), and Enterobacter species (9.4%). For all gram-negative isolates combined, the most active antimicrobials tested were meropenem, imipenem, and cefepime. The quinolones levofloxacin (MIC90, 2 microg/mL), ciprofloxacin (MIC90, 1 microg/mL), gatifloxacin (MIC90, 2 microg/mL), sparfloxacin (MIC90, 2 microg/mL), and trovafloxacin (MIC90, 2 microg/mL) were also active against most isolates. Bloodstream infection isolates from Latin America were uniformly more resistant to all classes of antimicrobial agents tested than were isolates from Canada or the United States. Resistance phenotypes consistent with extended-spectrum beta-lactamase production were also most common among E. coli and Klebsiella species from Latin America. Further investigation of the reasons for regional differences in resistance patterns is needed, as is ongoing surveillance to detect resistance trends and to guide antimicrobial use.

Latin America - epidemiology

United States - epidemiology

Humans

Male

Gram-Negative Bacteria - isolation & purification

Incidence

Bacteremia - microbiology

Gram-Negative Bacterial Infections - microbiology

Microbial Sensitivity Tests

Drug Resistance, Microbial

Gram-Negative Bacteria - drug effects

Canada - epidemiology

Cross Infection - microbiology

Gram-Negative Bacterial Infections - epidemiology

Bacteremia - epidemiology

Female

Population Surveillance

Cross Infection - epidemiology

Details

Title: Subtitle: Survey of bloodstream infections due to gram-negative bacilli: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, and Latin America for the SENTRY Antimicrobial Surveillance Program, 1997
Creators: D J Diekema - Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA. daniel-diekema@uiowa.edu
M A Pfaller
R N Jones
G V Doern
P L Winokur
A C Gales
H S Sader
K Kugler
M Beach
Contributors: SENTRY Participants Group (Author)
Resource Type: Journal article
Publication Details: Clinical infectious diseases, Vol.29(3), pp.595-607
Publisher: United States
DOI: 10.1086/598640
PMID: 10530454
ISSN: 1058-4838
eISSN: 1537-6591
Language: English
Date published: 09/1999
Academic Unit: Infectious Diseases; Epidemiology; Pathology; Medicine Administration; Internal Medicine
Record Identifier: 9983986372002771

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