Journal article
Survival Outcomes for Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck
Annals of otology, rhinology & laryngology, Vol.128(10), pp.949-955
10/01/2019
DOI: 10.1177/0003489419848786
PMID: 31091995
Abstract
Objectives: Survival outcomes for advanced non-melanoma skin cancers of the head and neck treated with surgical resection are not well described in the literature. We aimed to describe outcomes for T3 and T4 cutaneoous squamous cell carcinoma of the head or neck treated with surgical resection at 1 tertiary academic medical center. Methods: We analyzed a retrospective cohort of patients diagnosed with T3 or T4 cutaneous squamous cell carcinoma (SCC) of the head or neck from 2005 to 2016 treated with definitive surgical resection. Survival outcomes were examined using Kaplan-Meier analysis, and multivariate analysis was completed with Cox proportional hazard model. Results: Forty-three patients met inclusion criteria. The mean age at diagnosis was 74.7 years (SD = 10.2), and 34 (79.1%) patients were male. Twelve (27.9%) patients were immunosuppressed. Radical resection, defined as temporal bone resection, orbital exenteration, calvarial resection, mandibulectomy, or maxillectomy, was performed in 25 (58.1%) cases. Final surgical margins were positive in 19 (44.2%) cases. Patients with tumors of the scalp/neck had a 1-year survival probability of 85.7%, and the probability of survival 1 year after a neck dissection was greater than 93%. Conclusion: Anatomical subsites, specifically scalp/neck tumors, tended to have worse overall survival. Positive final margins tended to indicate a worse prognosis, and overall survival and recurrence were not significantly different among patients who underwent radical surgical resection compared to soft tissue resection.
Details
- Title: Subtitle
- Survival Outcomes for Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck
- Creators
- Christopher Blake Sullivan - University of IowaNicholas S. Andresen - 2 Johns Hopkins University, Baltimore, MD, USA.Nicholas Kendell - University of IowaZaid Al-Qurayshi - University of IowaNitin A. Pagedar - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Annals of otology, rhinology & laryngology, Vol.128(10), pp.949-955
- Publisher
- Sage
- DOI
- 10.1177/0003489419848786
- PMID
- 31091995
- ISSN
- 0003-4894
- eISSN
- 1943-572X
- Number of pages
- 7
- Grant note
- P30CA086862 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 10/01/2019
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984311443202771
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