Survival and Morbidity Outcomes for Very Low Birth Weight Infants With Down Syndrome

Nansi S BOGHOSSIAN; Nellie I HANSEN; Edward F BELL; Barbara J STOLL; Jeffrey C MURRAY; Abbot R LAPTOOK; Seetha SHANKARAN; Michele C WALSH; Abhik DAS; Rosemary D HIGGINS

doi:10.1542/peds.2010-1824

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Survival and Morbidity Outcomes for Very Low Birth Weight Infants With Down Syndrome

Journal article

Open access

Peer reviewed

Survival and Morbidity Outcomes for Very Low Birth Weight Infants With Down Syndrome

Nansi S BOGHOSSIAN, Nellie I HANSEN, Edward F BELL, Barbara J STOLL, Jeffrey C MURRAY, Abbot R LAPTOOK, Seetha SHANKARAN, Michele C WALSH, Abhik DAS and Rosemary D HIGGINS

Pediatrics (Evanston), Vol.126(6), pp.1132-1140

2010

DOI: 10.1542/peds.2010-1824

PMCID: PMC3059605

PMID: 21098157

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https://www.ncbi.nlm.nih.gov/pmc/articles/3059605View

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Abstract

Objective: Our objective was to compare survival and neonatal morbidity rates between very low birth weight (VLBW) infants with Down syndrome (DS) and VLBW infants with non-DS chromosomal anomalies, nonchromosomal birth defects (BDs), and no chromosomal anomaly or major BD. Methods: Data were collected prospectively for infants weighing 401 to 1500 g who were born and/or cared for at one of the study centers participating in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network in 1994-2008. Risk of death and morbidities, including patent ductus arteriosus (PDA), necrotizing enterocolitis (NEC), late-onset sepsis (LOS), retinopathy of prematurity, and bronchopulmonary dysplasia (BPD), were compared between VLBW infants with DS and infants in the other groups. Results: Infants with DS were at increased risk of death (adjusted relative risk: 2.47 [95% confidence interval: 2.00-3.07]), PDA, NEC, LOS, and BPD, relative to infants with no BDs. Decreased risk of death (relative risk: 0.40 [95% confidence interval: 0.31-0.52]) and increased risks of NEC and LOS were observed when infants with DS were compared with infants with other non-DS chromosomal anomalies. Relative to infants with nonchromosomal BDs, infants with DS were at increased risk of PDA and NEC. Conclusion: The increased risk of morbidities among VLBW infants with DS provides useful information for counseling parents and for anticipating the need for enhanced surveillance for prevention of these morbidities.

Epidemiology

Gynecology. Andrology. Obstetrics

Public health. Hygiene-occupational medicine

Public health. Hygiene

General aspects

Diseases of mother, fetus and pregnancy

Biological and medical sciences

Pregnancy. Fetus. Placenta

Medical sciences

Details

Title: Subtitle: Survival and Morbidity Outcomes for Very Low Birth Weight Infants With Down Syndrome
Creators: Nansi S BOGHOSSIAN - Department of Pediatrics, University of Iowa Health Care, Iowa City, Iowa, United States
Nellie I HANSEN - Statistics and Epidemiology Division, RTI International, Research Triangle Park, North Carolina, United States
Edward F BELL - Department of Pediatrics, University of Iowa Health Care, Iowa City, Iowa, United States
Barbara J STOLL - Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia
Jeffrey C MURRAY - Department of Pediatrics, University of Iowa Health Care, Iowa City, Iowa, United States
Abbot R LAPTOOK - Department of Pediatrics, School of Medicine, Brown University, Providence, Rhode Island, United States
Seetha SHANKARAN - Department of Pediatrics, School of Medicine, Wayne State University, Detroit, Michigan, United States
Michele C WALSH - Department of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States
Abhik DAS - RTI International, Rockville, Maryland, United States
Rosemary D HIGGINS - Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States
Resource Type: Journal article
Publication Details: Pediatrics (Evanston), Vol.126(6), pp.1132-1140
DOI: 10.1542/peds.2010-1824
PMID: 21098157
PMCID: PMC3059605
NLM abbreviation: Pediatrics
ISSN: 0031-4005
eISSN: 1098-4275
Publisher: American Academy of Pediatrics; Elk Grove Village, IL
Language: English
Date published: 2010
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research; Neonatology
Record Identifier: 9984025469302771

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