Journal article
Survival and consolidative radiotherapy in patients living with HIV and treated for diffuse large B-cell lymphoma
Reports of practical oncology and radiotherapy, Vol.25(6), pp.956-960
11/01/2020
DOI: 10.1016/j.rpor.2020.09.004
PMCID: PMC7569181
PMID: 33100911
Abstract
Objectives: Current guidelines tend to treat HIV positive (HIV+) patients as their seronegative counterparts with diffuse large B-cell lymphoma (DLBCL) but little is known about their radiotherapy responses differences.
Patients and Methods: A retrospective cohort of all consecutive HIV+ DBCL patients treated with chemotherapy between 2004 and 2018 was assessed. All patients had biopsy-proven lymphomas. They were included if the proposed radical treatment was done without progression or death during chemotherapy and had at least 6 months of follow-up or were followed until death.
Results: Fifty-three (53) patients were selected, with a median age at diagnosis of 41.39 years (20-65 years). Median follow-up of 35.16 months (1.4-178.7 months). Male patients accounted for 54.7% and most had a good performance in the ECOG scale at diagnoses (81.1% are ECOG 0-1). Median overall survival was not reached. Mean OS was 41.5 months with 16 deaths. Age had an impact on OS, with patients older than 60 years at more risk (p = 0.044), as did longtime use of HAART, with those that started antiretroviral therapy within the diagnose of the lymphoma at greatest risk (p = 0.044). RT did not have an impact on OS (p = 0.384) or PFS (p = 0.420), although survival curves show better OS in the radiotherapy group. Toxicities were rare, since none of the patients had grade 3 or superior toxicity.
Conclusion: RT did not impact survival or progression in our limited sample, but a longer OS may occur after the first-year post RT. RT should be tested in prospective data in the HIV+ population with DLBCL. (C) 2020 Greater Poland Cancer Centre. Published by Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Survival and consolidative radiotherapy in patients living with HIV and treated for diffuse large B-cell lymphoma
- Creators
- Lucas Coelho Casimiro - Instituto do Câncer do Estado de São PauloGeovanne Pedro Mauro - Universidade de São PauloCarolina Trindade Mello Medici - Barretos Canc Hosp, Dept Radiat Oncol, Porto Velho, RO, BrazilEduardo Weltman - Universidade de São Paulo
- Resource Type
- Journal article
- Publication Details
- Reports of practical oncology and radiotherapy, Vol.25(6), pp.956-960
- DOI
- 10.1016/j.rpor.2020.09.004
- PMID
- 33100911
- PMCID
- PMC7569181
- NLM abbreviation
- Rep Pract Oncol Radiother
- ISSN
- 1507-1367
- eISSN
- 2083-4640
- Publisher
- Via Medica
- Number of pages
- 5
- Language
- English
- Date published
- 11/01/2020
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984914017202771
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