Survival impact of malignant pancreatic neuroendocrine and islet cell neoplasm phenotypes

Christina L Roland; Aihua Bian; John C Mansour; Adam C Yopp; Glen C Balch; Rohit Sharma; Xian-Jin Xie; Roderich E Schwarz

doi:10.1002/jso.22118

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Survival impact of malignant pancreatic neuroendocrine and islet cell neoplasm phenotypes

Journal article

Peer reviewed

Survival impact of malignant pancreatic neuroendocrine and islet cell neoplasm phenotypes

Christina L Roland, Aihua Bian, John C Mansour, Adam C Yopp, Glen C Balch, Rohit Sharma, Xian-Jin Xie and Roderich E Schwarz

Journal of surgical oncology, Vol.105(6), pp.595-600

05/2012

DOI: 10.1002/jso.22118

PMCID: PMC5131366

PMID: 22006521

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http://doi.org/10.1002/jso.22118View

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Abstract

The low incidence of malignant "functional" (F) or "nonfunctional" (NF) neuroendocrine islet cell tumors (ICTs) of the pancreas represents a challenge to precise post-therapeutic survival prediction. This study examined the survival impact of malignant pancreatic ICT morphologic subtypes. A pancreatic ICT data set was created from a US-based population database from 1980-2004. Prognostic factors with survival impact and relationships between surgical therapy and overall survival (OS) were analyzed. There were 2,350 individuals with malignant ICTs. Histologic subtypes included carcinoid tumors, islet cell carcinomas, neuroendocrine carcinomas, and malignant gastrinomas, insulinomas, glucagonomas, or VIPomas. There was no difference in resection rates between FICTs and NFICTs (23% vs. 20%, P = ns). Median OS was 30 months, with group differences ranging from NE carcinomas (21) to VIPomas (96; P < 0.0001). Median OS of resected versus unresected FICTs was 172 versus 37 months, while that of NFICTs was 113 versus 18 months (P < 0.0001). Compared to neuroendocrine carcinomas, hazard ratios were: VIPomas 0.48, gastrinomas 0.65, carcinoid tumors 0.76, insulinomas 0.84, glucagonomas 0.93, and islet cell carcinomas 1.0. When controlled for other established prognostic parameters, histopathologic subtype assignment of pancreatic ICTs affects survival prediction. Resection is associated with superior survival for all tumor types.

Insulinoma - mortality

Lymph Nodes - pathology

Age Factors

United States

Humans

Middle Aged

Insulinoma - surgery

Male

Carcinoma, Islet Cell - pathology

Carcinoma, Islet Cell - surgery

Young Adult

Aged, 80 and over

Carcinoma, Islet Cell - mortality

Adult

Female

Pancreatic Neoplasms - mortality

Neuroendocrine Tumors - pathology

SEER Program

Pancreatic Neoplasms - pathology

Pancreatic Neoplasms - surgery

Proportional Hazards Models

Neuroendocrine Tumors - mortality

Insulinoma - pathology

Neuroendocrine Tumors - surgery

Aged

Details

Title: Subtitle: Survival impact of malignant pancreatic neuroendocrine and islet cell neoplasm phenotypes
Creators: Christina L Roland - Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-9155, USA
Aihua Bian
John C Mansour
Adam C Yopp
Glen C Balch
Rohit Sharma
Xian-Jin Xie
Roderich E Schwarz
Resource Type: Journal article
Publication Details: Journal of surgical oncology, Vol.105(6), pp.595-600
DOI: 10.1002/jso.22118
PMID: 22006521
PMCID: PMC5131366
NLM abbreviation: J Surg Oncol
ISSN: 1096-9098
eISSN: 1096-9098
Publisher: United States
Grant note: P30 CA142543 / NCI NIH HHS
Language: English
Date published: 05/2012
Academic Unit: Preventive and Community Dentistry; Biostatistics; Dental Research
Record Identifier: 9983917777602771

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