Journal article
Survival in macrophages induces enhanced virulence in Cryptococcus
mSphere, Vol.9(1), e0050423
01/30/2024
DOI: 10.1128/msphere.00504-23
PMCID: PMC10826345
PMID: 38073033
Abstract
Cryptococcosis begins in the lungs and can ultimately travel through the bloodstream to cause devastating infection in the central nervous system. In the zebrafish model, small amounts of cryptococcus inoculated into the bloodstream are initially phagocytosed and become far more capable of dissemination after they exit macrophages. Similarly, survival in the mouse lung produces cryptococcal cell types with enhanced dissemination. In this study, we have evaluated how phagocytosis changes the properties of
during pathogenesis. Macrophage-experienced cells (MECs) become "licensed" for enhanced virulence. They out-disseminate culture-grown cells in the fish and out-compete non-MECs in the mouse lung. Analysis of their cell surface demonstrates that MECs have increased availability of cell wall components mannose and chitin substances involved in provoking phagocytosis. These findings suggest how
might tune its cell surface to induce but survive repeated phagocytosis during early pathogenesis in the lung.
Details
- Title: Subtitle
- Survival in macrophages induces enhanced virulence in Cryptococcus
- Creators
- Jacquelyn A Nielson - University of IowaAndrew J Jezewski - University of IowaMelanie Wellington - University of IowaJ Muse Davis - Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- mSphere, Vol.9(1), e0050423
- DOI
- 10.1128/msphere.00504-23
- PMID
- 38073033
- PMCID
- PMC10826345
- NLM abbreviation
- mSphere
- eISSN
- 2379-5042
- Grant note
- name: HHS | National Institutes of Health, award: K08AI132720; name: HHS | National Institutes of Health, award: T32AI007511; name: HHS | National Institutes of Health, award: R01AI147541
- Language
- English
- Electronic publication date
- 12/11/2023
- Date published
- 01/30/2024
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984530275302771
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