Journal article
Survival of Human Normal Thyroid Cells after X-ray Irradiation
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol.47(3), pp.299-307
01/01/1985
DOI: 10.1080/09553008514550441
PMID: 3872283
Abstract
Normal thyroid cells from 25 individuals treated surgically for malignant or benign thyroid tumour were cultured in vitro and radiation induced cytotoxicity was studied. The mean lethal dose (D 0 ), quasi-threshold (D q ), and extrapolation number (n) of survival curves of actively dividing thyroid cells assayed by colony formation were estimated to be 92·9 ± 2·8 cGy (rad), 58·1 ± 6·9 cGy and 2·0 ± 0·1, respectively (average for 25 individuals ± standard error). These results suggest that proliferating human thyroid cells are more sensitive to X-rays than most other nonhaematologic mammalian cells in similar assays. Cell survival was not significantly affected by sex, age, disease or exposure to atomic bomb radiation of the cell donor. However, the number of samples currently available is too small for definite conclusions in this regard.
Details
- Title: Subtitle
- Survival of Human Normal Thyroid Cells after X-ray Irradiation
- Creators
- Toshio HiraokaRichard C MillerMichael N GouldKenneth J KopeckyHaruo EzakiNobuo TakeichiToshio ItoMichael P JonesKelly H Clifton
- Resource Type
- Journal article
- Publication Details
- International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol.47(3), pp.299-307
- Publisher
- Taylor & Francis
- DOI
- 10.1080/09553008514550441
- PMID
- 3872283
- ISSN
- 0020-7616
- eISSN
- 1362-3095
- Language
- English
- Date published
- 01/01/1985
- Academic Unit
- Statistics and Actuarial Science; Biostatistics; Public Policy Center (Archive)
- Record Identifier
- 9983985977502771
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