Journal article
Survival of Ugandan infants with subtype A and D HIV-1 infection (HIVNET 012)
Journal of acquired immune deficiency syndromes (1999), Vol.31(3), pp.327-330
2002
DOI: 10.1097/00126334-200211010-00009
PMID: 12439209
Abstract
Virologic factors may influence survival of HIV-1-infected infants. We compared survival of Ugandan infants with subtype A and subtype D HIV-1 infection. This study was performed in the context of the Ugandan clinical trial HIVNET 012, which compared the efficacy of single-dose nevirapine (NVP) and short-course zidovudine (AZT) for prevention of HIV-1 mother-to-child transmission. HIV-1 subtypes were determined by phylogenetic analysis of HIV-1 protease and reverse transcriptase sequences from 32 women in the NVP arm and 54 women in the AZT arm of HIVNET 012 whose infants were HIV-1 infected by 6 to 8 weeks of age. We found no association between HIV-1 subtype (A vs. D) and infant survival in this cohort. Further studies are needed to evaluate whether HIV-1 subtype influences clinical outcome in pediatric HIV-1 infection.
This work was supported by 1) the Elizabeth Glaser Pediatric AIDS Foundation; 2) the HIV Network for Prevention Trials (HIVNET) sponsored by the U.S. National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), and Department of Health and Human Services (DHHS) through contract N01-AI-35173 with Family Health International, contract N01-AI-45200 with the Fred Hutchinson Cancer Research Center, and subcontracts with Johns Hopkins University/Makerere University (NOI-AI-35173-417):(3) the HIV Prevention Trials Network (HPTN) sponsored by the NIAID, National Institutes of Child Health and Human Development (NICH/HD), National Institute on Drug Abuse, National Institute of Mental Health, and Office of AIDS Research of the NIH. DHHS (U01-AI-46745 and U01-AI-48054); 4) the Pediatric and Adult AIDS Clinical Trials Groups (NIH, Division of AIDS, NIAID); and 5) R29 34348 (NIH, Division of CH/HD). Reagents for HIV genotyping were provided by Applied Biosystems
Details
- Title: Subtitle
- Survival of Ugandan infants with subtype A and D HIV-1 infection (HIVNET 012)
- Creators
- Susan H ESHLEMAN - Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United StatesLaura A GUAY - Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United StatesThomas FLEMING - Fred Hutchinson Cancer Research Center, Seattle, Washington, United StatesAnthony MWATHA - Fred Hutchinson Cancer Research Center, Seattle, Washington, United StatesMartin MRACNA - Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United StatesGraziella BECKER-PERGOLA - Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United StatesPhilippa MUSOKE - Department of Pediatrics, Makerere University, Kampala, UgandaFrancis MMIRO - Department of Obstetrics and Gynaecology, Makerere University, Kampala, UgandaJ. Brooks JACKSON - Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States
- Resource Type
- Journal article
- Publication Details
- Journal of acquired immune deficiency syndromes (1999), Vol.31(3), pp.327-330
- Publisher
- Lippincott Williams & Wilkins; Hagerstown, MD
- DOI
- 10.1097/00126334-200211010-00009
- PMID
- 12439209
- ISSN
- 1525-4135
- eISSN
- 1944-7884
- Language
- English
- Date published
- 2002
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984046826302771
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