Journal article
Survivin inhibits anti-growth effect of p53 activated by aurora B
Biochemical and biophysical research communications, Vol.336(4), pp.1164-1171
11/04/2005
DOI: 10.1016/j.bbrc.2005.08.235
PMID: 16171786
Abstract
Genomic instability and apoptosis evasion are hallmarks of cancer, but the molecular mechanisms governing these processes remain elusive. Here, we found that survivin, a member of the apoptosis-inhibiting gene family, and aurora B kinase, a chromosomal passenger protein, were co-overexpressed in the various glioblastoma cell lines and tumors. Notably, exogenous introduction of the aurora B in human BJ cells was shown to decrease cell growth and increase the senescence-associated β-galactosidase activity by activation of p53 tumor suppressor. However, aurora B overexpression failed to inhibit cell proliferation in BJ and U87MG cells transduced with dominant-negative p53 as well as in p53
−/− mouse astrocytes. Aurora B was shown to increase centrosome amplification in the p53
−/− astrocytes. Survivin was shown to induce anchorage-independent growth and inhibit anti-proliferation and drug-sensitive apoptosis caused by aurora B. Overexpression of both survivin and aurora B further accelerated the proliferation of BJ cells. Taken together, the present study indicates that survivin should accelerate tumorigenesis by inhibiting the anti-proliferative effect of p53 tumor suppressor that is activated by aurora B in normal and glioblastoma cells containing intact p53.
Details
- Title: Subtitle
- Survivin inhibits anti-growth effect of p53 activated by aurora B
- Creators
- Ji-Eun Jung - University of SeoulTae-Kyung Kim - Korea UniversityJoong-Seob Lee - Korea UniversitySe-Yeong Oh - University of SeoulSungwook Kwak - Korea UniversityXun Jin - Korea UniversityJin-Young Sohn - University of SeoulMin-Keun Song - Korea UniversityYoung-Woo Sohn - Korea UniversitySoo-Yeon Lee - University of SeoulXumin Pian - Korea UniversityJang-Bo Lee - Korea UniversityYong Gu Chung - Korea UniversityYoung Ki Choi - Chungbuk National UniversitySeungkwon You - Korea UniversityHyunggee Kim - Korea University
- Resource Type
- Journal article
- Publication Details
- Biochemical and biophysical research communications, Vol.336(4), pp.1164-1171
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.bbrc.2005.08.235
- PMID
- 16171786
- ISSN
- 0006-291X
- eISSN
- 1090-2104
- Language
- English
- Date published
- 11/04/2005
- Academic Unit
- Neurosurgery
- Record Identifier
- 9984459621302771
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