Journal article
Susceptibility to Cytomegalovirus Infection May Be Dependent on the Cytokine Response to the Virus
Journal of Investigative Medicine, Vol.49(5), pp.434-441
09/2001
DOI: 10.2310/6650.2001.33788
PMID: 11523699
Abstract
BackgroundCytomegalovirus (CMV) infection is an important cause of morbidity and mortality in an immunocompromised host. Pulmonary infection with CMV results in an inflammatory response, which includes the local production of cytokines. Cytokine production stimulated by CMV infection serves to activate a series of immunologic responses involved in viral clearance. Previous work has demonstrated that different mouse strains express variable sensitivity to CMV infection.MethodsUsing mouse strains that express sensitive (BALB/cj) and resistant (C57BL/6) CMV phenotypes, we asked whether the differences in susceptibility to infection were caused by differences in pulmonary cytokine production after intraperitoneal infection with CMV.ResultsC57 mice demonstrated a higher total bronchoalveolar lavage (BAL) and BAL lymphocyte count at 3 and 7 days after intraperitoneal infection compared with BALB mice. There were no differences in BAL cytokine production; however, we were able to demonstrate differences in CMV DNA load in the lungs of BALB mice compared with that of C57 mice. In addition, there appeared to be increased whole-lung production of the TH2 cytokine IL-10 in the BALB mice versus the C57 mice.ConclusionsThis observation suggests that the genetic susceptibility to CMV infection may, in part, be regulated by differences in cytokines production within the local environment.
Details
- Title: Subtitle
- Susceptibility to Cytomegalovirus Infection May Be Dependent on the Cytokine Response to the Virus
- Creators
- Lois J GeistSara L Hinde
- Resource Type
- Journal article
- Publication Details
- Journal of Investigative Medicine, Vol.49(5), pp.434-441
- DOI
- 10.2310/6650.2001.33788
- PMID
- 11523699
- ISSN
- 1081-5589
- eISSN
- 1708-8267
- Language
- English
- Date published
- 09/2001
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Provost Office Administration; Internal Medicine
- Record Identifier
- 9984213293802771
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