Sustained Adrenergic Activation of YAP1 Induces Anoikis Resistance in Cervical Cancer Cells

Yang Li; Shanshan Yang; Nouara C Sadaoui; Wei Hu; Santosh K Dasari; Lingegowda S Mangala; Yunjie Sun; Shuangtao Zhao; Linghua Wang; Yuan Liu; Lois M Ramondetta; Ke Li; Chong Lu; Yu Kang; Steve W Cole; Susan K Lutgendorf; Anil K Sood

doi:10.1016/j.isci.2020.101289

Back

Sustained Adrenergic Activation of YAP1 Induces Anoikis Resistance in Cervical Cancer Cells

Journal article

Open access

Peer reviewed

Sustained Adrenergic Activation of YAP1 Induces Anoikis Resistance in Cervical Cancer Cells

Yang Li, Shanshan Yang, Nouara C Sadaoui, Wei Hu, Santosh K Dasari, Lingegowda S Mangala, Yunjie Sun, Shuangtao Zhao, Linghua Wang, Yuan Liu, …

iScience, Vol.23(7), pp.101289-101289

07/24/2020

DOI: 10.1016/j.isci.2020.101289

PMID: 32623336

Files and links (1)

url

https://doi.org/10.1016/j.isci.2020.101289View

Published (Version of record) Open Access

Abstract

Chronic stress-related hormones modulate tumor pathogenesis at multiple levels; however, the molecular pathways involved in stress and cervical cancer progression are not well understood. We established a preclinical orthotopic mouse model of cervical cancer and used the model to show that daily restraint stress increased tumor growth and metastatic tumor burden. Exposure to norepinephrine significantly protected cervical cancer cells from anoikis. We demonstrated that YAP1 was dephosphorylated and translocated from the cytoplasm to the nucleus by norepinephrine, a process initiated by ADRB2/cAMP/protein kinase A activation. Furthermore, anoikis resistance and YAP1 activation induced by norepinephrine could be rescued by a broad β-adrenergic receptor antagonist, propranolol. Collectively, our results provide a pivotal molecular pathway for disrupting pro-tumor neuroendocrine signaling in cervical cancer. •Daily restraint stress increases tumor growth and metastatic tumor burden•Norepinephrine protects cervical cancer cells from anoikis•Norepinephrine induces YAP1 dephosphorylation and nuclear translocation•Norepinephrine - induced anoikis resistance can be reversed by propranolol Biological Sciences; Cancer

Biological Sciences

Cancer

Details

Title: Subtitle: Sustained Adrenergic Activation of YAP1 Induces Anoikis Resistance in Cervical Cancer Cells
Creators: Yang Li - Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Shanshan Yang - Department of Gynecologic Radiotherapy, Harbin Medical University Cancer Hospital, Harbin, China
Nouara C Sadaoui - Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Wei Hu - Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Santosh K Dasari - Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Lingegowda S Mangala - Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Yunjie Sun - Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Shuangtao Zhao - Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Linghua Wang - Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Yuan Liu - Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Lois M Ramondetta - Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Ke Li - Department of Obstetrics and Gynecology of Shanghai Medical School, Fudan University, Shanghai, China
Chong Lu - Department of Obstetrics and Gynecology of Shanghai Medical School, Fudan University, Shanghai, China
Yu Kang - Department of Obstetrics and Gynecology of Shanghai Medical School, Fudan University, Shanghai, China
Steve W Cole - Cousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, Division of Hematology/Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Susan K Lutgendorf - Department of Psychological & Brain Sciences, Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, Department of Urology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA
Anil K Sood - Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Resource Type: Journal article
Publication Details: iScience, Vol.23(7), pp.101289-101289
DOI: 10.1016/j.isci.2020.101289
PMID: 32623336
NLM abbreviation: iScience
ISSN: 2589-0042
eISSN: 2589-0042
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000054, name: National Cancer Institute; DOI: 10.13039/100000048, name: American Cancer Society; DOI: 10.13039/100002956, name: Foundation for Women's Cancer
Language: English
Date published: 07/24/2020
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
Record Identifier: 9984065772202771

Metrics

11 Record Views

14 Times Cited - Web of Science