Sustained benefit of continuous glucose monitoring on A1C, glucose profiles, and hypoglycemia in adults with type 1 diabetes

Bruce Bode; Roy W Beck; Dongyuan Xing; Lisa Gilliam; Irl Hirsch; Craig Kollman; Lori Laffel; Katrina J Ruedy; William V Tamborlane; Stuart Weinzimer; Howard Wolpert; Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group

doi:10.2337/dc09-0846

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Sustained benefit of continuous glucose monitoring on A1C, glucose profiles, and hypoglycemia in adults with type 1 diabetes

Journal article

Open access

Peer reviewed

Sustained benefit of continuous glucose monitoring on A1C, glucose profiles, and hypoglycemia in adults with type 1 diabetes

Bruce Bode, Roy W Beck, Dongyuan Xing, Lisa Gilliam, Irl Hirsch, Craig Kollman, Lori Laffel, Katrina J Ruedy, William V Tamborlane, Stuart Weinzimer, …

Diabetes care, Vol.32(11), pp.2047-2049

11/2009

DOI: 10.2337/dc09-0846

PMCID: PMC2768224

PMID: 19675193

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Abstract

To evaluate long-term effects of continuous glucose monitoring (CGM) in intensively treated adults with type 1 diabetes. We studied 83 of 86 individuals >or=25 years of age with type 1 diabetes who used CGM as part of a 6-month randomized clinical trial in a subsequent 6-month extension study. RESULTS After 12 months, median CGM use was 6.8 days per week. Mean change in A1C level from baseline to 12 months was -0.4 +/- 0.6% (P < 0.001) in subjects with baseline A1C >or=7.0%. A1C remained stable at 6.4% in those with baseline A1C <7.0%. The incidence rate of severe hypoglycemia was 21.8 and 7.1 events per 100 person-years in the first and last 6 months, respectively. Time per day with glucose levels in the range of 71-180 mg/dl increased significantly (P = 0.02) from baseline to 12 months. In intensively treated adults with type 1 diabetes, CGM use and benefit can be sustained for 12 months.

Hypoglycemia - diagnosis

Hypoglycemia - epidemiology

Body Weight

Blood Glucose - analysis

Monitoring, Ambulatory - methods

Glycated Hemoglobin A - metabolism

Humans

Hypoglycemia - prevention & control

Hyperglycemia - blood

Hyperglycemia - diagnosis

Motivation

Time Factors

Diabetes Mellitus, Type 1 - blood

Adult

Hypoglycemia - blood

Blood Glucose - metabolism

Diabetes Mellitus, Type 1 - psychology

Details

Title: Subtitle: Sustained benefit of continuous glucose monitoring on A1C, glucose profiles, and hypoglycemia in adults with type 1 diabetes
Creators: Bruce Bode
Roy W Beck
Dongyuan Xing
Lisa Gilliam
Irl Hirsch
Craig Kollman
Lori Laffel
Katrina J Ruedy
William V Tamborlane
Stuart Weinzimer
Howard Wolpert
Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
Contributors: Michael J Tansey (Contributor) - University of Iowa, Stead Family Department of Pediatrics
Resource Type: Journal article
Publication Details: Diabetes care, Vol.32(11), pp.2047-2049
DOI: 10.2337/dc09-0846
PMID: 19675193
PMCID: PMC2768224
NLM abbreviation: Diabetes Care
ISSN: 0149-5992
eISSN: 1935-5548
Language: English
Date published: 11/2009
Academic Unit: Endocrinology and Diabetes; Stead Family Department of Pediatrics
Record Identifier: 9984093500802771

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