Journal article
Sustained reductions in oxipurinol renal clearance during a restricted diet
Clinical pharmacology and therapeutics, Vol.41(6), pp.616-621
06/1987
DOI: 10.1038/clpt.1987.84
PMID: 3581647
Abstract
The renal clearance of oxipurinol, the major metabolite of allopurinol, was studied in six healthy subjects during normal and restricted (low protein and low calorie) diets. A 600 mg oral dose of allopurinol was administered after 7 days of a normal diet (100 mg protein/day) and again after 2 and 4 weeks of a restricted diet (19 gm protein/day). The renal clearance of oxipurinol was reduced from 19.6 ±1.5 ml/ min during the normal diet to 10.9 ± 0.8 and 12.0 ± 0.9 ml/min (both P < 0.001) during the restricted diet at 2 and 4 weeks, respectively. These changes in oxipurinol renal clearance paralleled changes in uric acid renal clearance. Furthermore, the plasma oxipurinol half‐life was increased from 27.0 ±1.7 hours during the normal diet to 51.1 ± 4.3 and 45.7 ± 3.7 hours (both P < 0.001) during the restricted diet at 2 and 4 weeks, respectively. We conclude that dietary protein and calorie restriction cause a sustained reduction in the elimination of oxipurinol.
Clinical Pharmacology and Therapeutics (1987) 41, 616–621; doi:10.1038/clpt.1987.84
Details
- Title: Subtitle
- Sustained reductions in oxipurinol renal clearance during a restricted diet
- Creators
- Glen D Park - University of IowaWilliam G Berlinger - University of IowaReynold Spector - University of IowaTherese M Kitt - University of IowaEva Tsalikian - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical pharmacology and therapeutics, Vol.41(6), pp.616-621
- DOI
- 10.1038/clpt.1987.84
- PMID
- 3581647
- ISSN
- 0009-9236
- eISSN
- 1532-6535
- Number of pages
- 6
- Grant note
- College of Medicine National Institutes of Health General Clinical Research Center Support (RR59) Burroughs Wellcome Fund
- Language
- English
- Date published
- 06/1987
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093323102771
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