Journal article
Swine models in translational research and medicine
Veterinary pathology, Vol.61(4), pp.512-523
07/2024
DOI: 10.1177/03009858231222235
PMID: 38197394
Abstract
Swine are increasingly studied as animal models of human disease. The anatomy, size, longevity, physiology, immune system, and metabolism of swine are more like humans than traditional rodent models. In addition, the size of swine is preferred for surgical placement and testing of medical devices destined for humans. These features make swine useful for biomedical, pharmacological, and toxicological research. With recent advances in gene-editing technologies, genetic modifications can readily and efficiently be made in swine to study genetic disorders. In addition, gene-edited swine tissues are necessary for studies testing and validating xenotransplantation into humans to meet the critical shortfall of viable organs versus need. Underlying all of these biomedical applications, the knowledge of husbandry, background diseases and lesions, and biosecurity needs are important for productive, efficient, and reproducible research when using swine as a human disease model for basic research, preclinical testing, and translational studies.
Details
- Title: Subtitle
- Swine models in translational research and medicine
- Creators
- David K Meyerholz - University of Iowa, Iowa City, IAEric R Burrough - Iowa State UniversityNicole Kirchhof - Medtronic FoundationDouglas J Anderson - University of Alabama at BirminghamKristi L Helke - Medical University of South Carolina
- Resource Type
- Journal article
- Publication Details
- Veterinary pathology, Vol.61(4), pp.512-523
- Publisher
- Sage
- DOI
- 10.1177/03009858231222235
- PMID
- 38197394
- eISSN
- 1544-2217
- Grant note
- DOI: 10.13039/100000897, name: Cystic Fibrosis Foundation; name: Revivicor; DOI: 10.13039/100000002, name: National Institutes of Health, award: HL09184; DOI: 10.13039/100000002, name: National Institutes of Health, award: HL152960; DOI: 10.13039/100000002, name: National Institutes of Health, award: HL163556; DOI: 10.13039/100007150, name: United Therapeutics Corporation; name: Lung Biotechnology PBC
- Language
- English
- Electronic publication date
- 01/10/2024
- Date published
- 07/2024
- Academic Unit
- Pathology
- Record Identifier
- 9984544952702771
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