Journal article
Swiss Multicenter Ab Interno XEN45 Gel Stent Study: 2-Year Real-World Data
Ophthalmology and therapy, Vol.13(6), pp.1513-1525
06/01/2024
DOI: 10.1007/s40123-024-00917-y
PMCID: PMC11109057
PMID: 38581605
Abstract
Introduction The aim of this study was to investigate the 2-year postoperative efficacy of the XEN45 Gel Stent by evaluating the reduction of intraocular pressure (IOP) and the need for eye pressure-lowering medications in a multicenter setting in Switzerland.Methods Patients with various types of glaucoma who received a XEN45 Gel Stent with or without combined phacoemulsification cataract surgery at five hospitals in Switzerland were retrospectively enrolled. Pre- and postoperative IOP, the number of antiglaucoma medications, and the need of subsequent interventions to control IOP were assessed. The success rate was defined as a >= 20% reduction of IOP 2 years postoperatively without the need for subsequent glaucoma surgery.Results A total of 345 eyes were included: 44.3% with primary open-angle, 42.0% pseudoexfoliation, and 13.7% with other types of glaucoma. Of these, 206 patients were followed for 2 years. Preoperatively, the mean IOP was 26.3 +/- 8.9 mmHg and the mean number of antiglaucoma medications administered was 3.0 +/- 1.3. Two years postoperatively, the success rate was 66.0% (95% confidence interval 59.3-72.1%), the IOP had dropped by 43.8% to 14.8 +/- 5.7 mmHg, and the number of medications was reduced by a mean of 2.0 +/- 1.7 per day. Postoperative complications and the need for interventions remained low.Conclusion The XEN45 Gel Stent successfully reduced IOP and the number of antiglaucoma drugs in most patients at 2 years postoperatively.
Details
- Title: Subtitle
- Swiss Multicenter Ab Interno XEN45 Gel Stent Study: 2-Year Real-World Data
- Creators
- Anthia Papazoglou - Kantonsspital AarauRene Hoehn - University Hospital of BernMegir Schawkat - University Hospital of BernChristoph Tappeiner - University Hospital of BernMilko Iliev - University Hospital of BernKonstantin Gugleta - University Hospital of BaselGiulia Saletta - University Hospital of BaselAndrea Wiencierz - University Hospital of BaselBarbara Wagels - University of St. GallenMargarita G. Todorova - University of ZurichIwona Krzyzanowska - University of ZurichMarc Toeteberg-Harms - University of ZurichMarkus Tschopp - University of Bern
- Resource Type
- Journal article
- Publication Details
- Ophthalmology and therapy, Vol.13(6), pp.1513-1525
- Publisher
- SPRINGER INT PUBL AG
- DOI
- 10.1007/s40123-024-00917-y
- PMID
- 38581605
- PMCID
- PMC11109057
- ISSN
- 2193-8245
- eISSN
- 2193-6528
- Number of pages
- 13
- Grant note
- Forschungsrat des Kantonsspitals Aarau
- Language
- English
- Date published
- 06/01/2024
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984696567502771
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