Journal article
Sydenham's chorea: not gone and not forgotten
Seminars in pediatric neurology, Vol.10(1), pp.11-19
03/2003
DOI: 10.1016/S1071-9091(02)00004-9
PMID: 12785743
Abstract
Sydenham's chorea is an ancient disease that continues to afflict large numbers of children throughout the world. A major manifestation of rheumatic fever, Sydenham's chorea is commonly manifested by movement disorder and psychiatric problems, and also may be a marker for a life-threatening carditis. Because Sydenham's chorea is triggered by streptococcal pharyngitis, the most important component of its therapy is antibiotic prophylaxis against further streptococcal infections. Because the pathogenesis of Sydenham's chorea includes the production of anti-basal ganglia antibodies, therapies that modulate immune function or that restore neurotransmitter balance within the basal ganglia may be effective for Sydenham's chorea. Recent reports have suggested that Sydenham's chorea may be part of a spectrum of neuropsychiatric syndromes induced by streptococcal infection.
Details
- Title: Subtitle
- Sydenham's chorea: not gone and not forgotten
- Creators
- Daniel J Bonthius - Department of Pediatrics, College of Medicine, University of Iowa, Iowa City 52242, USABahri Karacay
- Resource Type
- Journal article
- Publication Details
- Seminars in pediatric neurology, Vol.10(1), pp.11-19
- Publisher
- United States
- DOI
- 10.1016/S1071-9091(02)00004-9
- PMID
- 12785743
- ISSN
- 1071-9091
- eISSN
- 1558-0776
- Grant note
- P30-HD27748 / NICHD NIH HHS K08 NS02007-01A2 / NINDS NIH HHS
- Language
- English
- Date published
- 03/2003
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984065826302771
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