Symmetry of foot alignment and ankle flexibility in paediatric Charcot–Marie–Tooth disease

Joshua Burns; Robert Ouvrier; Tim Estilow; Rosemary Shy; Matilde Laurá; Kate Eichinger; Francesco Muntoni; Mary M Reilly; Davide Pareyson; Gyula Acsadi; Michael E Shy; Richard S Finkel

doi:10.1016/j.clinbiomech.2012.02.006

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Symmetry of foot alignment and ankle flexibility in paediatric Charcot–Marie–Tooth disease

Journal article

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Symmetry of foot alignment and ankle flexibility in paediatric Charcot–Marie–Tooth disease

Joshua Burns, Robert Ouvrier, Tim Estilow, Rosemary Shy, Matilde Laurá, Kate Eichinger, Francesco Muntoni, Mary M Reilly, Davide Pareyson, Gyula Acsadi, …

Clinical biomechanics (Bristol), Vol.27(7), pp.744-747

08/2012

DOI: 10.1016/j.clinbiomech.2012.02.006

PMCID: PMC3389135

PMID: 22424781

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Abstract

Charcot–Marie–Tooth disease is the most common inherited nerve disorder and typically presents with pes cavus foot deformity and ankle equinus during childhood. Level in the variation of symmetry of musculoskeletal lower limb involvement across the clinical population is unknown, despite early reports describing gross asymmetry. We measured foot alignment and ankle flexibility of the left and right limbs using accurate and reliable standardised paediatric outcome measures in 172 patients aged 3–20years with a variety of disease subtypes recruited from the United States, United Kingdom, Italy and Australia. While a large range of differences existed between left and right feet for a small proportion of children, there was no overall significant difference between limbs. There are two important implications of these findings. Children with Charcot–Marie–Tooth disease generally exhibit symmetrical foot alignment and ankle flexibility between limbs. As such, analysing one limb only for biomechanical-related research is appropriate and satisfies the independence requirements for statistical analysis. However, because there are large differences between feet for a small proportion of children, an individualised limb-focused approach to clinical care is required.

Ankle

Charcot–Marie–Tooth disease

Children

Foot posture index

Pes cavus

Foot

Details

Title: Subtitle: Symmetry of foot alignment and ankle flexibility in paediatric Charcot–Marie–Tooth disease
Creators: Joshua Burns - The Children's Hospital at Westmead, Sydney, NSW, Australia
Robert Ouvrier - The Children's Hospital at Westmead, Sydney, NSW, Australia
Tim Estilow - Neuromuscular Program, The Children's Hospital of Philadelphia, PA, USA
Rosemary Shy - Department of Pediatrics, The Children's Hospital of Michigan, Detroit, MI, USA
Matilde Laurá - MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, Queen Square, London, UK
Kate Eichinger - University of Rochester, Rochester, NY, USA
Francesco Muntoni - UCL Institute of Child Health, London, UK
Mary M Reilly - MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, Queen Square, London, UK
Davide Pareyson - IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
Gyula Acsadi - Neurology Division, Connecticut Children's Medical Center, Hartford, CT, USA
Michael E Shy - School of Medicine, Wayne State University, Detroit, MI, USA
Richard S Finkel - Neuromuscular Program, The Children's Hospital of Philadelphia, PA, USA
Resource Type: Journal article
Publication Details: Clinical biomechanics (Bristol), Vol.27(7), pp.744-747
DOI: 10.1016/j.clinbiomech.2012.02.006
PMID: 22424781
PMCID: PMC3389135
NLM abbreviation: Clin Biomech (Bristol)
ISSN: 0268-0033
eISSN: 1879-1271
Publisher: Elsevier Ltd
Language: English
Date published: 08/2012
Academic Unit: Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984020613402771

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