Journal article
Sympathetic Activation By Hypoxia and Hypercapnia - Implications for Sleep Apnea
Clinical and experimental hypertension (1993), Vol.A10(S1), pp.413-422
1988
DOI: 10.3109/10641968809075998
PMID: 3072127
Abstract
In normal humans, both hypoxia and hypercapnia result in sympathetic nerve activation, and when combined, i.e. hypoxic hypercapnia, synergistically increase sympathetic activity. Apnea during the hypoxic and hypercapnic stress results in further increases in sympathetic activity. Borderline hypertensive humans have exaggerated sympathetic nerve responses to hypoxia. Hypertensives are also prone to sleep apnea. We suggest that sleep apnea may result in very high levels of sympathetic activity which may contribute to daytime hypertension and/or precipitate cardiovascular catastrophe in hypertensive people during sleep.
Details
- Title: Subtitle
- Sympathetic Activation By Hypoxia and Hypercapnia - Implications for Sleep Apnea
- Creators
- V. K Somers - 1Departments of Internal Medicine and Physiology The Cardiovascular Center, The University of Iowa College of Medicine, Iowa City, Iowa, 52242A. L Mark - 1Departments of Internal Medicine and Physiology The Cardiovascular Center, The University of Iowa College of Medicine, Iowa City, Iowa, 52242F. M Abboud - 1Departments of Internal Medicine and Physiology The Cardiovascular Center, The University of Iowa College of Medicine, Iowa City, Iowa, 52242
- Resource Type
- Journal article
- Publication Details
- Clinical and experimental hypertension (1993), Vol.A10(S1), pp.413-422
- Publisher
- Informa UK Ltd
- DOI
- 10.3109/10641968809075998
- PMID
- 3072127
- ISSN
- 1064-1963
- eISSN
- 1525-6006
- Language
- English
- Date published
- 1988
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025583302771
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