Journal article
Sympathetic Nerves Protect Against Stroke in Stroke-Prone Hypertensive Rats: A Preliminary Report
Hypertension (Dallas, Tex. 1979), Vol.3(3 Suppl I), pp.I-124-I-127
05/1981
DOI: 10.1161/01.HYP.3.3_Pt_2.I124
PMID: 7262975
Abstract
SUMMARY Studies were performed to determine whether sympathetic nerves protect against stroke in hypertensive rats. The superior cervical ganglion was removed on one side in 28 stroke-prone spontaneously hypertensive rats (SHRSP) when the rats were 4 weeks old. The rats were fed Japanese rat chow and 1% saline drinking water. When the rats were 19 weeks old, systolic pressure was 206±4 mm Hg (mean±SE). All rats died between 19 and 23 weeks of age. Microscopic and bistological examination demonstrated cerebral hemorrhage in seven rats. All the hemorrhages occurred in the denervated hemispheres. Iscbemic cerebral infarctions were found in 13 rats; in 10 rats, the infarcts were only in the denervated hemisphere. Pathological changes of cerebral arteries (hyalinosis, flbrinoid changes, and thrombus formation) were observed primarily in denervated hemispheres. Wall-to-lumen ratio was less in arteries of the denervated hemisphere than in arteries of the innervated hemisphere. These preliminary observations suggest that denerration of cerebral vessels increases susceptibility to stroke and inhibits development of cerebral vascular hypertrophy in SHRSP. (Hypertension 3 (supp I)I-124-I-127, 1981)
Details
- Title: Subtitle
- Sympathetic Nerves Protect Against Stroke in Stroke-Prone Hypertensive Rats: A Preliminary Report
- Creators
- SEIZO SADOSHIMA - From the Departments of Internal Medicine and Pharmacology, and the Cardiovascular Center, College of Medicine, University of Iowa, and Veterans Administration Hospitals, Iowa City, IowaDAVID BUSIJAMICHAEL BRODYDONALD HEISTAD
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.3(3 Suppl I), pp.I-124-I-127
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.HYP.3.3_Pt_2.I124
- PMID
- 7262975
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 05/1981
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040368302771
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