Journal article
Sympathetic Nerves Protect the Blood-Brain Barrier in Stroke-Prone Spontaneously Hypertensive Rats
Hypertension (Dallas, Tex. 1979), Vol.4(6), pp.904-907
11/1982
DOI: 10.1161/01.HYP.4.6.904
PMID: 7141613
Abstract
Disruption of the blood-brain barrier may play a major role in the pathogenesis of hypertensive encephalopathy. In this study we determined whether sympathetic nerves to cerebral vessels protect the blood-brain barrier during chronic hypertension. We removed the cervical sympathetic ganglion on one side in 24 stroke-prone hypertensive rats when they were 1 month old. After signs of cerebral dysfunction developed at the mean age of 160 ± 5 days (SE), we injected I-albumin and Evans blue dye intravenously to evaluate the permeability of the blood-brain barrier. Twelve rats showed disruption of the barrier without histological evidence of cerebral hemorrhage or infarction. The barrier was disrupted in the denervated hemisphere in all 12 rats and in the innervated hemisphere in only three rats (p < 0.05). Permeability to I-albumin was 3.53 ± 0.83 (brain albumin × 100/blood albumin) in areas of the cerebrum stained with blue dye and 0.24 ± 0.02 in unstained areas (p < 0.05). We conclude that sympathetic nerves protect the blood-brain barrier against disruption during chronic hypertension and thereby may protect against hypertensive encephalopathy. (Hypertension 4904–907, 1982)
Details
- Title: Subtitle
- Sympathetic Nerves Protect the Blood-Brain Barrier in Stroke-Prone Spontaneously Hypertensive Rats
- Creators
- SEIZO SADOSHIMA - From the Department of Internal Medicine, Veterans Administration Medical Center, and the Cardiovascular Center, University of Iowa College of Medicine, Iowa City, IowaDONALD HEISTAD
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.4(6), pp.904-907
- DOI
- 10.1161/01.HYP.4.6.904
- PMID
- 7141613
- NLM abbreviation
- Hypertension
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Publisher
- American Heart Association, Inc
- Language
- English
- Date published
- 11/1982
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040576002771
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