Journal article
Sympathetic Nervous System Mediation of Acute Cardiovascular Actions of γ2-Melanocyte-Stimulating Hormone
Hypertension (Dallas, Tex. 1979), Vol.7(3 Suppl I), pp.I-145-I-150
05/1985
Abstract
Peptides of the pro-opiocortin class produce pronounced cardiovascular and natriuretic actions. We have investigated the acute cardiovascular effects of one of the most potent members of this class, γ2-melanocyte stimulating hormone (γ2-MSH), in rats. Pressor actions of γ2-MSH administered systemicaMy were eliminated by ganglionic blockade with chlorisondamine. Peripheral cholinergic blockade failed to affect either the pressor or cardioaccelerator responses to γ2-MSH. Administration of γ2MSH (2.0–10.0 μg) produced vasoconstriction primarily in the mesenteric and hindlimb vascular beds, while the renal bed showed little response. Infusions of phenylephrine produced pressor responses similar to those found with γ2-MSH, which were accompanied by a decrease in heart rate and vasoconstriction in the mesenteric and renal vascular beds. Hemodynamic changes produced by γ2-MSH and phenylephrine were blocked or attenuated by α1-adrenergic receptor blockade with prazosin. Direct injection of γ2-MSH into the renal artery produced an acute renal vasoconstriction that was not attenuated by α1-adrenergic or ganglionic blockade. These findings and the results of previous publications are consistent with the hypothesis that γ2-MSH may produce a centrally mediated activation of the sympathetic nervous system, have direct vasoconstriction actions on the renal vasculature, and inhibit baroreceptor function to produce an increase in blood pressure without an accompanying bradycardia.
Details
- Title: Subtitle
- Sympathetic Nervous System Mediation of Acute Cardiovascular Actions of γ2-Melanocyte-Stimulating Hormone
- Creators
- MICHAEL Callahan - Departments of Psychology, Pharmacology, and the Cardiovascular Center, The University of Iowa, Iowa City, Iowa, and the Departments of Physiology and Pharmacology, and Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North CarolinaROBERT KirbyDENNIS WolffJACK StrandhoyJOHN LymangroverALAN JohnsonKENNETH Gruber
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.7(3 Suppl I), pp.I-145-I-150
- Publisher
- American Heart Association, Inc
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 05/1985
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984214759902771
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