Journal article
Sympathetic Neural Control in Humans with Anxiety-related Disorders
COMPREHENSIVE PHYSIOLOGY, Vol.12(1), pp.3085-3117
12/29/2021
DOI: 10.1002/cphy.c210027
PMID: 34964121
Abstract
Numerous conceptual models are used to describe the dynamic responsiveness of physiological systems to environmental pressures, originating with Claude Bernard???s milieu int??rieur and extend-ing to more recent models such as allostasis. The impact of stress and anxiety upon these regulatory processes has both basic science and clinical relevance, extending from the pioneering work of Hans Selye who advanced the concept that stress can significantly impact physiological health and function. Of particular interest within the current article, anxiety is independently associated with cardiovascular risk, yet mechanisms underlying these associations remain equivocal. This link between anxiety and cardiovascular risk is relevant given the high prevalence of anxiety in the general population, as well as its early age of onset. Chronically anxious populations, such as those with anxiety disorders (i.e., generalized anxiety disorder, panic disorder, specific phobias, etc.) offer a human model that interrogates the deleterious effects that chronic stress and allostatic load can have on the nervous system and cardiovascular function. Further, while many of these disorders do not appear to exhibit baseline alterations in sympathetic neural activity, reactivity to mental stress offers insights into applicable, real-world scenarios in which heightened sympa-thetic reactivity may predispose those individuals to elevated cardiovascular risk. This article also assesses behavioral and lifestyle modifications that have been shown to concurrently improve anxiety symptoms, as well as sympathetic control. Lastly, future directions of research will be dis-cussed, with a focus on better integration of psychological factors within physiological studies examining anxiety and neural cardiovascular health. ?? 2022 American Physiological Society. Compr Physiol 12:3085-3117, 2022.
Details
- Title: Subtitle
- Sympathetic Neural Control in Humans with Anxiety-related Disorders
- Creators
- Jeremy A. Bigalke - Montana State UniversityJason R. Carter - Montana State University
- Resource Type
- Journal article
- Publication Details
- COMPREHENSIVE PHYSIOLOGY, Vol.12(1), pp.3085-3117
- DOI
- 10.1002/cphy.c210027
- PMID
- 34964121
- NLM abbreviation
- Compr Physiol
- eISBN
- 9780470650714; 0470650710
- ISSN
- 2040-4603
- eISSN
- 2040-4603
- Publisher
- Wiley
- Number of pages
- 33
- Grant note
- AA-024892 / National Institute on Alcohol Abuse and Alcoholism; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA)
- Language
- English
- Date published
- 12/29/2021
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9985219856302771
Metrics
1 Record Views