Journal article
Sympathetic nervous system regulation of the tumour microenvironment
Nature reviews. Cancer, Vol.15(9), pp.563-572
09/2015
DOI: 10.1038/nrc3978
PMCID: PMC4828959
PMID: 26299593
Abstract
The peripheral autonomic nervous system (ANS) is known to regulate gene expression in primary tumours and their surrounding microenvironment. Activation of the sympathetic division of the ANS in particular modulates gene expression programmes that promote metastasis of solid tumours by stimulating macrophage infiltration, inflammation, angiogenesis, epithelial-mesenchymal transition and tumour invasion, and by inhibiting cellular immune responses and programmed cell death. Haematological cancers are modulated by sympathetic nervous system (SNS) regulation of stem cell biology and haematopoietic differentiation programmes. In addition to identifying a molecular basis for physiologic stress effects on cancer, these findings have also identified new pharmacological strategies to inhibit cancer progression in vivo.
Details
- Title: Subtitle
- Sympathetic nervous system regulation of the tumour microenvironment
- Creators
- Steven W Cole - Department of Medicine, Division of Hematology-Oncology, David Geffen School of Medicine, University of California, Los Angeles (UCLA) Molecular Biology Institute, 11-934 Factor Building, UCLA School of Medicine, Los Angeles California 90095-1678, USA; and the Jonsson Comprehensive Cancer Center, UCLA, 8-684 Factor Building, Box 951781, Los Angeles, California 90095-1781, USAArchana S Nagaraja - Department of Gynecologic Oncology; and the Department of Cancer Biology, University of Texas M. D. Anderson Comprehensive Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USASusan K Lutgendorf - Department of Psychology, E11 Seashore Hall, Department of Obstetrics and Gynecology, 200 Hawkins Drive; Department of Urology, 3 Roy Carver Pavilion, 200 Hawkins Drive; and the Holden Comprehensive Cancer Center, 200 Hawkins Drive, University of Iowa, Iowa City 52242-1407, USAPaige A Green - Basic Biobehavioral and Psychological Sciences Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, United States National Cancer Institute, Building 9609 Room 3E133, 9609 Medical Center Drive, Rockville, Maryland 20850, USAAnil K Sood - Department of Gynecologic Oncology; and the Department of Cancer Biology, University of Texas M. D. Anderson Comprehensive Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Cancer, Vol.15(9), pp.563-572
- DOI
- 10.1038/nrc3978
- PMID
- 26299593
- PMCID
- PMC4828959
- NLM abbreviation
- Nat Rev Cancer
- ISSN
- 1474-1768
- eISSN
- 1474-1768
- Publisher
- England
- Grant note
- CA083639 / NCI NIH HHS CA104825 / NCI NIH HHS R01 CA104825 / NCI NIH HHS CA177909 / NCI NIH HHS CA116778 / NCI NIH HHS R01 CA177909 / NCI NIH HHS AG017265 / NIA NIH HHS P50 CA098258 / NCI NIH HHS R01 CA109298 / NCI NIH HHS CA098258 / NCI NIH HHS R37 AG033590 / NIA NIH HHS CA109298 / NCI NIH HHS R01 CA116778 / NCI NIH HHS R01 CA140933 / NCI NIH HHS CA140933 / NCI NIH HHS P30 CA016672 / NCI NIH HHS CA151668 / NCI NIH HHS U54 CA151668 / NCI NIH HHS P50 CA083639 / NCI NIH HHS AG033590 / NIA NIH HHS P30 AG017265 / NIA NIH HHS
- Language
- English
- Date published
- 09/2015
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984002311302771
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