Journal article
Sympathetic responses to stimulation of area postrema in decerebrate and anesthetized rats
American journal of physiology. Heart and circulatory physiology, Vol.268(3), pp.H1086-H1095
03/01/1995
DOI: 10.1152/ajpheart.1995.268.3.H1086
PMID: 7900862
Abstract
The effects of electrical and chemical stimulation of the area postrema (AP) on mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA) were examined in urethan- and pentobarbital sodium-anesthetized rats and in unanesthetized decerebrate rats. The AP was electrically stimulated over a range of frequencies (10–100 Hz) and intensities (10–80 microA) with a pulse duration of 0.2 or 1.0 ms. The excitatory amino acid L-glutamate (100 or 200 mM) was microinjected into the AP to preferentially stimulate neuronal cell bodies. In urethan-anesthetized rats, electrical stimulation of the AP decreased MAP and RSNA. In pentobarbital sodium-anesthetized rats, MAP and RSNA were markedly increased by AP stimulation. In unanesthetized decerebrate rats, increases in MAP and RSNA were also observed during electrical AP stimulation. Microinjection of L-glutamate had no effect on MAP and RSNA in anesthetized or in unanesthetized rats. These results indicate that electrical AP stimulation increases sympathetic output in the unanesthetized decerebrate rat and that anesthesia modifies this sympathetic response. The findings also suggest that peripheral responses to L-glutamate and electrical stimulation of the AP are mediated over different central pathways.
Details
- Title: Subtitle
- Sympathetic responses to stimulation of area postrema in decerebrate and anesthetized rats
- Creators
- Allison A Hegarty - Cardiovascular Center, University of Iowa College of Medicine, Iowa CityLinda F Hayward - Cardiovascular Center, University of Iowa College of Medicine, Iowa CityRobert B Felder - Cardiovascular Center, University of Iowa College of Medicine, Iowa City
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.268(3), pp.H1086-H1095
- DOI
- 10.1152/ajpheart.1995.268.3.H1086
- PMID
- 7900862
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Language
- English
- Date published
- 03/01/1995
- Academic Unit
- Iowa Neuroscience Institute; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984065381202771
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