Journal article
Sympathetic terminal mediation of the acute cardiovascular response of γ2-MSH
Journal of the autonomic nervous system, Vol.24(1), pp.179-182
1988
DOI: 10.1016/0165-1838(88)90146-4
Abstract
Peptides of the ACTH
4–10/γ
2-MSH3
3–9 class produce pressor and cardioaccelerator effects upon i.v. administration. These actions appear to be mediated by peripheral catecholamines. To ascertain the role of sympathetic nerve terminals in the cardiovascular effects of these peptides, we used bretylium tosylate to prevent nerve terminal release of norepinephrine. Pretreatment with bretylium significantly attenuated the pressor and cardioaccelerator responses of
γ
2-MSH, and shifted the peak of the remaining responses to a later time point. It appears that the acute cardiovascular response to γ-MSH administration depends primarily on the release of sympathetic terminal norepinephrine, though some contribution from other pressor systems such as adrenal catecholamines is possible.
Details
- Title: Subtitle
- Sympathetic terminal mediation of the acute cardiovascular response of γ2-MSH
- Creators
- Michael F Callahan - Department of Psychology, and The Cardiovascular Center, University of Iowa, Iowa City, IA 52242 U.S.ARobert F Kirby - Department of Psychology, and The Cardiovascular Center, University of Iowa, Iowa City, IA 52242 U.S.AAlan Kim Johnson - Department of Psychology, and The Cardiovascular Center, University of Iowa, Iowa City, IA 52242 U.S.AKenneth A Gruber - Department of Psychology, and The Cardiovascular Center, University of Iowa, Iowa City, IA 52242 U.S.A
- Resource Type
- Journal article
- Publication Details
- Journal of the autonomic nervous system, Vol.24(1), pp.179-182
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0165-1838(88)90146-4
- ISSN
- 0165-1838
- eISSN
- 1872-7476
- Language
- English
- Date published
- 1988
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984214759802771
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