Symptom Management for Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline

Kimberly Perez; Jaydira Del Rivero; Erin B Kennedy; Sandip Basu; Aman Chauhan; Heidi M Connolly; Arvind N Dasari; Alexandra Gangi; Callisia N Clarke; Julie Hallet; James R Howe; Erin Grady; Jana Ivanidze; Erik S Mittra; Sarah B White; Nitya P Raj; Namrata Vijayvergia; Mark A Lewis; Jennifer A Chan; Pamela L Kunz; Josh Mailman; Junaid Arshad; Heloisa P Soares; Simron Singh; Chandrika Chandrasekharan; Michael C Soulen; Eva Tiensuu Janson; Thorvardur R Halfdanarson; Jonathan R Strosberg; Emily K Bergsland

doi:10.1200/OP-25-00133

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Symptom Management for Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline

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Symptom Management for Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline

Kimberly Perez, Jaydira Del Rivero, Erin B Kennedy, Sandip Basu, Aman Chauhan, Heidi M Connolly, Arvind N Dasari, Alexandra Gangi, Callisia N Clarke, Julie Hallet, …

JCO oncology practice, Vol.22(1), pp.19-35

01/2026

DOI: 10.1200/OP-25-00133

PMID: 40344544

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Abstract

To develop a clinical practice guideline and recommendations for symptom management of patients with well-differentiated grade 1 to grade 3 metastatic gastroenteropancreatic neuroendocrine tumors. ASCO convened an Expert Panel to develop a clinical practice guideline by reviewing the literature for relevant guidelines, systematic reviews, randomized controlled trials (RCTs), and observational studies to develop recommendations for clinical practice. The literature review identified eight guidelines, 19 systematic reviews, and three RCTs that informed the development of guideline recommendations. Recommendations are included for carcinoid syndrome, carcinoid heart disease and carcinoid crisis, and functional pancreatic neuroendocrine tumor syndromes. Recommendations are provided for surgical management, liver-directed therapy, and systemic therapy options, as well as palliative care. Limited guidance is provided for sequencing of interventions.Additional information is available at www.asco.org/gastrointestinal-cancer-guidelines.

Details

Title: Subtitle: Symptom Management for Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline
Creators: Kimberly Perez - Dana-Farber Cancer Institute
Jaydira Del Rivero - National Cancer Institute
Erin B Kennedy - American Society of Clinical Oncology
Sandip Basu - Bhabha Atomic Research Centre
Aman Chauhan - University of Miami Health System
Heidi M Connolly - Mayo Clinic
Arvind N Dasari - The University of Texas MD Anderson Cancer Center
Alexandra Gangi - Cedars-Sinai Medical Center
Callisia N Clarke - Medical College of Wisconsin
Julie Hallet - Sunnybrook Health Science Centre
James R Howe - University of Iowa, Iowa City, IA
Erin Grady - Stanford Medicine
Jana Ivanidze - Weill Cornell Medicine
Erik S Mittra - University of Portland
Sarah B White - Medical College of Wisconsin
Nitya P Raj - Memorial Sloan Kettering Cancer Center
Namrata Vijayvergia - Fox Chase Cancer Center
Mark A Lewis - Intermountain Healthcare
Jennifer A Chan - Dana-Farber Cancer Institute
Pamela L Kunz - Yale School of Medicine
Josh Mailman - NorCal CarciNET Community, Oakland, CA
Junaid Arshad - University of Arizona Cancer Center
Heloisa P Soares - University of Utah
Simron Singh - Sunnybrook Health Science Centre
Chandrika Chandrasekharan - University of Iowa, Hematology, Oncology, and Blood & Marrow Transplantation
Michael C Soulen - University of Pennsylvania Health System
Eva Tiensuu Janson - Uppsala University
Thorvardur R Halfdanarson - Mayo Clinic
Jonathan R Strosberg - Moffitt Cancer Center
Emily K Bergsland - University of California, San Francisco
Resource Type: Journal article
Publication Details: JCO oncology practice, Vol.22(1), pp.19-35
DOI: 10.1200/OP-25-00133
PMID: 40344544
NLM abbreviation: JCO Oncol Pract
ISSN: 2688-1535
eISSN: 2688-1535
Publisher: American Society of Clinical Oncology
Language: English
Electronic publication date: 05/09/2025
Date published: 01/2026
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Surgery; Internal Medicine
Record Identifier: 9984820569402771

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