Symptom burden and outcomes among patients with early-onset versus average-onset neuroendocrine neoplasms

Suriya Baskar; Rishi R Patel; Brandon Rose; Sawyer Bawek; Ashish Samaddar; Tao Xu; Michael O'Rorke; Deepak Vadehera; Timothy J Brown; Nicholas Hornstein; Udhayvir Singh Grewal

doi:10.1007/s00520-026-10919-0

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Symptom burden and outcomes among patients with early-onset versus average-onset neuroendocrine neoplasms

Journal article

Peer reviewed

Symptom burden and outcomes among patients with early-onset versus average-onset neuroendocrine neoplasms

Suriya Baskar, Rishi R Patel, Brandon Rose, Sawyer Bawek, Ashish Samaddar, Tao Xu, Michael O'Rorke, Deepak Vadehera, Timothy J Brown, Nicholas Hornstein, …

Supportive care in cancer, Vol.34(7), 689

06/25/2026

DOI: 10.1007/s00520-026-10919-0

PMID: 42348007

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Abstract

The incidence of neuroendocrine neoplasms (NENs) is rising, particularly among younger patients, but data comparing early-onset (EO-NENs) and average-onset (AO-NENs) remain limited. Using the National Inpatient Sample (2016-2020), we compared patient characteristics, symptom burden, and outcomes between these groups. Hospitalizations with NENs were identified using ICD-10 codes and stratified as EO (< 50 years) or AO (≥ 50 years). Demographics, comorbidities, symptom burden, interventions, and outcomes were compared using t-tests, chi-squared tests, and logistic regression analysis (p < 0.001 significant because of Bonferroni correction). We identified 22,555 EO-NEN and 149,470 AO-NEN hospitalizations. EO-NEN patients were more often female (55% vs. 49%). Private insurance was more common in EO-NENs (59% vs. 28%, p < 0.001). EO-NENs were more frequently intestinal or thymic in origin. Symptom burden was higher in EO-NENs, including nausea/vomiting (8.6% vs. 4.7%), constipation (13.9% vs. 10.8%), abdominal pain (1.9% vs. 1.3%), and anxiety (18.3% vs. 14.0%; all p < 0.001). AO-NENs experienced more acute complications (heart failure, cardiac arrest). Multivariate analysis showed no significant difference in odds of inpatient mortality between both cohorts. EO-NEN hospitalizations had higher rates of treatment with chemotherapy (6.1% vs. 4.2%) and surgical resection. EO-NENs represent a clinically distinct subset with greater symptom burden but fewer acute complications and similar mortality compared to AO-NENs. These findings highlight the need for age-tailored care pathways and further research into the unique biology driving EO-NENs.

Adult

Age Factors

Age of Onset

Aged

Female

Hospitalization - statistics & numerical data

Humans

Incidence

Logistic Models

Male

Middle Aged

Neuroendocrine Tumors - epidemiology

Neuroendocrine Tumors - pathology

Neuroendocrine Tumors - therapy

Symptom Burden

United States - epidemiology

Young Adult

Details

Title: Subtitle: Symptom burden and outcomes among patients with early-onset versus average-onset neuroendocrine neoplasms
Creators: Suriya Baskar - Brooklyn Hospital Center
Rishi R Patel - University Hospitals of Cleveland
Brandon Rose - Baylor University Medical Center
Sawyer Bawek - Cleveland Clinic
Ashish Samaddar - Northwell Health
Tao Xu - University of Iowa
Michael O'Rorke - University of Iowa
Deepak Vadehera - Roswell Park Comprehensive Cancer Center
Timothy J Brown - The University of Texas Southwestern Medical Center
Nicholas Hornstein - Northwell Health
Udhayvir Singh Grewal - Emory University
Resource Type: Journal article
Publication Details: Supportive care in cancer, Vol.34(7), 689
DOI: 10.1007/s00520-026-10919-0
PMID: 42348007
NLM abbreviation: Support Care Cancer
ISSN: 0941-4355
eISSN: 1433-7339
Publisher: Springer Nature
Language: English
Date published: 06/25/2026
Academic Unit: Epidemiology; Pathology
Record Identifier: 9985176646902771

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