Journal article
Symptoms of Lower Urinary Tract Dysfunction Research Network
The Journal of urology, Vol.196(1), pp.146-152
07/2016
DOI: 10.1016/j.juro.2016.01.007
PMCID: PMC4914448
PMID: 26784646
Abstract
To address gaps in understanding and treating lower urinary tract symptoms, the NIDDK created the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). The goals of LURN are to work collaboratively to 1) identify and explain the important subtypes of lower urinary tract symptoms; 2) improve the measurement of patient experiences of lower urinary tract symptoms; 3) disseminate novel findings to researchers, clinicians and patients; and 4) generate data, research tools and biological samples for future studies.
As a first step in understanding subtypes of lower urinary tract symptoms, LURN will focus on disorders of urinary sensation (eg urgency) and their causes. These are being examined with respect to patient experience, organism or systemic factors, genitourinary organs and tissues, and cellular/molecular factors. This is being achieved via an observational cohort study that is currently enrolling patients with lower urinary tract symptoms (target number 1,000) and that will extensively characterize patients with lower urinary tract symptoms. Future studies embedded within the observational cohort study will focus on neuroimaging and sensory testing, biomarkers and organ based factors. To advance the science of measurement of lower urinary tract symptoms, LURN is also developing and evaluating a comprehensive set of self-report questions to provide more granular assessments of lower urinary tract symptoms.
LURN has taken its first steps by developing a framework for studying lower urinary tract symptom subtypes.
In developing this framework, LURN is choosing an initial domain on which to focus (sensory experiences), and creating and executing protocols designed to improve measurement of self-reported symptoms and identify patient subtypes.
Details
- Title: Subtitle
- Symptoms of Lower Urinary Tract Dysfunction Research Network
- Creators
- Claire C Yang - Department of Urology, University of Washington, Seattle, WashingtonKevin P Weinfurt - Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North CarolinaRobert M Merion - Arbor Research Collaborative for Health and the Department of Surgery, University of Michigan, Ann Arbor, MichiganZiya Kirkali - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. Electronic address: ziya.kirkali@nih.govLURN Study Group
- Contributors
- Bradley A Erickson (Contributor) - University of Iowa, Urology
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.196(1), pp.146-152
- DOI
- 10.1016/j.juro.2016.01.007
- PMID
- 26784646
- PMCID
- PMC4914448
- NLM abbreviation
- J Urol
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Publisher
- United States
- Grant note
- U01 DK100017 / NIDDK NIH HHS U01 DK097779 / NIDDK NIH HHS U01 DK100011 / NIDDK NIH HHS U01 DK097780 / NIDDK NIH HHS Z99 DK999999 / NULL U01 DK099879 / NIDDK NIH HHS U01 DK097772 / NIDDK NIH HHS U01 DK097776 / NIDDK NIH HHS K12 DK100024 / NIDDK NIH HHS U01 DK099932 / NIDDK NIH HHS
- Language
- English
- Date published
- 07/2016
- Academic Unit
- Urology
- Record Identifier
- 9984051723302771
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