Synchronous and Metastatic Papillary and Follicular Thyroid Carcinomas with Unique Molecular Signatures

Vincent Cracolici; Ibro Mujacic; Sabah Kadri; Mir Alikhan; Nifang Niu; Jeremy P Segal; Lauren E Rosen; David H Sarne; Adam Morgan; Samy Desouky; Nicole A Cipriani

doi:10.1007/s12022-017-9491-6

Back

Synchronous and Metastatic Papillary and Follicular Thyroid Carcinomas with Unique Molecular Signatures

Journal article

Peer reviewed

Synchronous and Metastatic Papillary and Follicular Thyroid Carcinomas with Unique Molecular Signatures

Vincent Cracolici, Ibro Mujacic, Sabah Kadri, Mir Alikhan, Nifang Niu, Jeremy P Segal, Lauren E Rosen, David H Sarne, Adam Morgan, Samy Desouky, …

Endocrine pathology, Vol.29(1), pp.9-14

03/01/2018

DOI: 10.1007/s12022-017-9491-6

PMID: 28710706

View Online

Abstract

Despite the relatively high prevalence of thyroid cancer, the occurrence of multiple synchronous, distinct subtypes of primary thyroid carcinoma is uncommon. The incidental finding of papillary thyroid microcarcinoma in a gland with a biologically relevant follicular or medullary carcinoma is more frequent than the synchronous occurrence of multiple clinically significant carcinomas. We report a case of synchronous papillary and follicular thyroid carcinomas metastatic to lymph node and bone, respectively. Next generation sequencing showed BRAF V600E mutation in the primary papillary carcinoma and NRAS Q61R mutation in the primary follicular carcinoma and bony metastasis. To our knowledge, this is the first reported case of synchronous and metastatic primary papillary and follicular carcinomas, and the first report of synchronous BRAF V600E mutated papillary and NRAS mutated follicular carcinoma.

Adenocarcinoma, Follicular - genetics

Adenocarcinoma, Follicular - pathology

Carcinoma, Papillary - genetics

Carcinoma, Papillary - pathology

Female

GTP Phosphohydrolases - genetics

Humans

Lymphatic Metastasis - genetics

Lymphatic Metastasis - pathology

Membrane Proteins - genetics

Middle Aged

Mutation

Neoplasms, Multiple Primary - genetics

Neoplasms, Multiple Primary - pathology

Proto-Oncogene Proteins B-raf - genetics

Thyroid Neoplasms - genetics

Thyroid Neoplasms - pathology

Details

Title: Subtitle: Synchronous and Metastatic Papillary and Follicular Thyroid Carcinomas with Unique Molecular Signatures
Creators: Vincent Cracolici - University of Chicago Medical Center
Ibro Mujacic - University of Chicago Medical Center
Sabah Kadri - University of Chicago Medical Center
Mir Alikhan - University of Chicago Medical Center
Nifang Niu - University of Chicago Medical Center
Jeremy P Segal - University of Chicago Medical Center
Lauren E Rosen - University of Chicago Medical Center
David H Sarne - University of Chicago Medical Center
Adam Morgan - St. Mary's Hospital
Samy Desouky - St. Mary's Hospital
Nicole A Cipriani - University of Chicago Medical Center
Resource Type: Journal article
Publication Details: Endocrine pathology, Vol.29(1), pp.9-14
DOI: 10.1007/s12022-017-9491-6
PMID: 28710706
ISSN: 1046-3976
eISSN: 1559-0097
Language: English
Date published: 03/01/2018
Academic Unit: Stead Family Department of Pediatrics; Medical Genetics and Genomics
Record Identifier: 9984701648802771

Metrics

4 Record Views

14 Times Cited - Web of Science