Journal article
Syndromes of Thrombotic Microangiopathy
The New England journal of medicine, Vol.371(19), pp.1846-1848
11/06/2014
DOI: 10.1056/NEJMc1410951
PMID: 25372103
Abstract
To the Editor:
In their review of the thrombotic microangiopathy syndromes, George and Nester (Aug. 14 issue)
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do not mention the option of treating severe neurologic deficits in patients with shiga toxin–mediated hemolytic–uremic syndrome (ST-HUS) with IgG depletion through immunoadsorption.
2
In the 2011 outbreak in northern Germany, the delay in the onset of neurologic symptoms (5 to 12 days after the onset of diarrhea; mean and median, 8.0 days) strongly suggested antibody involvement in the pathogenesis of these symptoms. Consequently, all 12 patients had substantial improvement, and 10 of them fully recovered after IgG depletion through immunoadsorption, despite the failure . . .
Details
- Title: Subtitle
- Syndromes of Thrombotic Microangiopathy
- Creators
- Shraga Aviner - Barzilai University Medical Center, Ashkelon, IsraelHaim Bibi - Barzilai University Medical Center, Ashkelon, IsraelFabio Villa - Ente Ospedaliero Cantonale, Bellinzona, SwitzerlandMartin Kömhoff - University Medical Center Groningen, Groningen, the NetherlandsMarcus T Roofthooft - University Medical Center Groningen, Groningen, the NetherlandsFrancjan Spronsen - University Medical Center Groningen, Groningen, the NetherlandsJames N George - University of Oklahoma Health Sciences Center, Oklahoma City, OKCarla M Nester - University of Iowa, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- The New England journal of medicine, Vol.371(19), pp.1846-1848
- DOI
- 10.1056/NEJMc1410951
- PMID
- 25372103
- NLM abbreviation
- N Engl J Med
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Publisher
- Massachusetts Medical Society
- Language
- English
- Date published
- 11/06/2014
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984093342402771
Metrics
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