Journal article
Synergistic Association of House Endotoxin Exposure and Ambient Air Pollution with Asthma Outcomes
American journal of respiratory and critical care medicine, Vol.200(6), pp.712-720
09/15/2019
DOI: 10.1164/rccm.201809-1733oc
PMCID: PMC6775869
PMID: 30965018
Abstract
House endotoxin and ambient air pollution are risk factors for asthma; however, the effects of their coexposure on asthma are not well characterized.
To examine potential synergistic associations of coexposure to house dust endotoxin and ambient air pollutants with asthma outcomes.
We analyzed data of 6,488 participants in the National Health and Nutrition Examination Survey 2005-2006. Dust from bedding and bedroom floor was analyzed for endotoxin content. The Community Multiscale Air Quality Modeling System (CMAQ) and Downscaler Model data were used to determine annual average particulate matter ≤2.5 μm in aerodynamic diameter (PM
), ozone (O
), and nitrogen dioxide (NO
) exposures at participants' residential locations. The associations of the coexposures with asthma outcomes were assessed and tested for synergistic interaction.
In adjusted analysis, PM
(CMAQ) (odds ratio [OR], 1.12; 95% confidence interval [CI], 1.07-1.18), O
(Downscaler Model) (OR, 1.07; 95% CI, 1.02-1.13), and log
NO
(CMAQ) (OR, 3.15; 95% CI, 1.33-7.45) were positively associated with emergency room visits for asthma in the past 12 months. Coexposure to elevated concentrations of house dust endotoxin and PM
(CMAQ) was synergistically associated with the outcome, increasing the odds by fivefold (OR, 5.01; 95% CI, 2.54-9.87). A synergistic association was also found for coexposure to higher concentrations of endotoxin and NO
in children (OR, 3.45; 95% CI, 1.65-7.18).
Coexposure to elevated concentrations of residential endotoxin and ambient PM
in all participants and NO
in children is synergistically associated with increased emergency room visits for asthma. Therefore, decreasing exposure to both endotoxin and air pollution may help reduce asthma morbidity.
Details
- Title: Subtitle
- Synergistic Association of House Endotoxin Exposure and Ambient Air Pollution with Asthma Outcomes
- Creators
- Angelico Mendy - Department of Occupational and Environmental Health, University of Iowa, Iowa City, IowaJesse Wilkerson - Social & Scientific Systems, Inc., Durham, North CarolinaPaïvi M Salo - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina; andCharles H Weir - Office of Emergency Management, U.S. Department of Health and Human Services, Atlanta, GeorgiaLydia Feinstein - Social & Scientific Systems, Inc., Durham, North CarolinaDarryl C Zeldin - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina; andPeter S Thorne - Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.200(6), pp.712-720
- Publisher
- United States
- DOI
- 10.1164/rccm.201809-1733oc
- PMID
- 30965018
- PMCID
- PMC6775869
- ISSN
- 1535-4970
- eISSN
- 1535-4970
- Grant note
- P30 ES005605 / NIEHS NIH HHS Z01 ES025041 / Intramural NIH HHS HHSN273201600002C / NIEHS NIH HHS
- Language
- English
- Date published
- 09/15/2019
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health
- Record Identifier
- 9984001084102771
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