Journal article
Synergistic, growth-inhibitory effects of chlorhexidine and copper combinations on Streptococcus mutans, Actinomyces viscosus, and Actinomyces naeslundii
Journal of dental research, Vol.72(2), pp.524-528
02/1993
DOI: 10.1177/00220345930720020901
PMID: 8423250
Abstract
The purpose of this investigation was to determine whether chlorhexidine combined with copper would exert a synergistic, growth-inhibitory effect against selected oral bacteria. Actinomyces viscosus, Actinomyces naeslundii, and Streptococcus mutans were all susceptible to chlorhexidine individually, with S. mutans displaying the highest sensitivity. Much higher concentrations of copper were needed to achieve growth inhibition of the micro-organisms tested. Determination of minimum inhibitory concentrations (MICs) of chlorhexidine and Cu2+ combinations suggested synergistic activity. Bactericidal kinetics assays confirmed synergism of chlorhexidine and Cu2+ combinations with 1 to 2 log greater decreases in viable cell numbers compared with chlorhexidine alone. Under the constraints of the conditions employed, these data demonstrate the efficacy of chlorhexidine and Cu2+ combinations against the oral bacteria tested. These studies suggest that a chlorhexidine and copper formulation could be useful as a mouthrinse in helping control cariogenic micro-organisms and/or in the treatment of gingivitis.
Details
- Title: Subtitle
- Synergistic, growth-inhibitory effects of chlorhexidine and copper combinations on Streptococcus mutans, Actinomyces viscosus, and Actinomyces naeslundii
- Creators
- D R Drake - Dows Institute for Dental Research, University of Iowa, Iowa City 52242W GrigsbyA CardenzanaD Dunkerson
- Resource Type
- Journal article
- Publication Details
- Journal of dental research, Vol.72(2), pp.524-528
- Publisher
- United States
- DOI
- 10.1177/00220345930720020901
- PMID
- 8423250
- ISSN
- 0022-0345
- eISSN
- 1544-0591
- Language
- English
- Date published
- 02/1993
- Academic Unit
- Endodontics; Dental Research
- Record Identifier
- 9984065991602771
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