Journal article
Synonymous substitutions in the Xdh gene of Drosophila: heterogeneous distribution along the coding region
Genetics (Austin), Vol.144(3), pp.1053-1062
11/1996
PMCID: PMC1207601
PMID: 8913749
Abstract
The Xdh (rosy) region of Drosophila subobscura has been sequenced and compared to the homologous region of D. pseudoobscura and D. melanogaster. Estimates of the numbers of synonymous substitutions per site (Ks) confirm that Xdh has a high synonymous substitution rate. The distributions of both nonsynonymous and synonymous substitutions along the coding region were found to be heterogeneous. Also, no relationship has been detected between Ks estimates and codon usage bias along the gene, in contrast with the generally observed relationship among genes. This heterogeneous distribution of synonymous substitutions along the Xdh gene, which is expression-level independent, could be explained by a differential selection pressure on synonymous sites along the coding region acting on mRNA secondary structure. The synonymous rate in the Xdh coding region is lower in the D. subobscura than in the D. pseudoobscura lineage, whereas the reverse is true for the Adh gene.
Details
- Title: Subtitle
- Synonymous substitutions in the Xdh gene of Drosophila: heterogeneous distribution along the coding region
- Creators
- J M Comeron - Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, SpainM Aguadé
- Resource Type
- Journal article
- Publication Details
- Genetics (Austin), Vol.144(3), pp.1053-1062
- Publisher
- United States
- PMID
- 8913749
- PMCID
- PMC1207601
- ISSN
- 0016-6731
- eISSN
- 1943-2631
- Language
- English
- Date published
- 11/1996
- Academic Unit
- Biology
- Record Identifier
- 9983992069702771
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