Synovitis in Knee Osteoarthritis Assessed by Contrast-enhanced Magnetic Resonance Imaging (MRI) is Associated with Radiographic Tibiofemoral Osteoarthritis and MRI-detected Widespread Cartilage Damage: The MOST Study

Ali GUERMAZI; Daichi HAYASHI; Yuqing Zhang; Michael C NEVITT; David T FELSON; Frank W ROEMER; Yanyan Zhu; Jingbo Niu; Michel D CREMA; M. Kassim JAVAID; Monica D MARRA; John A LYNCH; George Y EL-KHOURY

doi:10.3899/jrheum.130541

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Synovitis in Knee Osteoarthritis Assessed by Contrast-enhanced Magnetic Resonance Imaging (MRI) is Associated with Radiographic Tibiofemoral Osteoarthritis and MRI-detected Widespread Cartilage Damage: The MOST Study

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Synovitis in Knee Osteoarthritis Assessed by Contrast-enhanced Magnetic Resonance Imaging (MRI) is Associated with Radiographic Tibiofemoral Osteoarthritis and MRI-detected Widespread Cartilage Damage: The MOST Study

Ali GUERMAZI, Daichi HAYASHI, Yuqing Zhang, Michael C NEVITT, David T FELSON, Frank W ROEMER, Yanyan Zhu, Jingbo Niu, Michel D CREMA, M. Kassim JAVAID, …

Journal of rheumatology, Vol.41(3), pp.501-508

2014

DOI: 10.3899/jrheum.130541

PMCID: PMC5476295

PMID: 24429179

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Abstract

Objective. To examine the cross-sectional association of whole-knee synovitis assessed by contrast-enhanced magnetic resonance imaging (CEMRI) with radiographic tibiofemoral osteoarthritis (OA), non-CEMRI-assessed cartilage damage, and meniscal status. Methods. Multicenter Osteoarthritis Study (MOST) is a cohort study of people with or at high risk of knee OA. Subjects are a subset of MOST who volunteered for both CEMRI and non-CEMRI. Using CEMRI, synovitis was assessed at 11 sites and graded 0–2 at each site. Presence of “whole-knee synovitis” was defined as the synovitis score of ≥ 1 at any site from each knee. Cartilage and meniscal damage was evaluated using non-CEMRI based on the Whole Organ MRI Score. Logistic regression was used to assess associations of synovitis with radiographic OA (Kellgren-Lawrence grade ≥ 2), widespread cartilage damage, and meniscal damage, adjusting for age, sex, and body mass index (BMI). Additional analyses were performed excluding subjects who had chondrocalcinosis on radiography and those taking antiinflammatory medications. Results. Four hundred four subjects were included (mean age 58.8 ± 7.0 yrs, BMI 29.6 ± 4.9 kg/m2, 45.5% women). On CEMRI, the maximum synovitis score across 11 sites in each knee was 0 in 106 knees (26.2%), 1 in 135 (33.4%), and 2 in 163 (40.4%). Synovitis was associated with radiographic OA [adjusted OR (aOR) 3.25, 95% CI 1.98–5.35] and widespread cartilage damage (aOR 1.91, 95% CI 1.24–2.92). Severe meniscal damage showed a borderline significant association with synovitis (aOR 1.74, 95% CI 0.99–3.04). Additional analyses as described did not notably change the results. Conclusion. CEMRI-detected synovitis is strongly associated with tibiofemoral radiographic OA and MRI-detected widespread cartilage damage.

Osteoarthritis

Miscellaneous. Osteoarticular involvement in other diseases

Biological and medical sciences

Medical sciences

Diseases of the osteoarticular system

Details

Title: Subtitle: Synovitis in Knee Osteoarthritis Assessed by Contrast-enhanced Magnetic Resonance Imaging (MRI) is Associated with Radiographic Tibiofemoral Osteoarthritis and MRI-detected Widespread Cartilage Damage: The MOST Study
Creators: Ali GUERMAZI - Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA, United States
Daichi HAYASHI - Department of Radiology, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, CT, United States
Yuqing Zhang - Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA, United States
Michael C NEVITT - Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA, United States
David T FELSON - Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA, United States
Frank W ROEMER - Department of Radiology, Boston University School of Medcine, and Department of Radiology, University of Erlangen, Erlangen, Germany
Yanyan Zhu - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, United States
Jingbo Niu - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, United States
Michel D CREMA - Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem, Sao Paulo, Brazil
M. Kassim JAVAID - Oxford UK National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
Monica D MARRA - Department of Radiology, Boston University School of Medicine, and Department of Radiology, HCor and Teleimagem, Sao Paulo, Brazil
John A LYNCH - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, United States
George Y EL-KHOURY - Department of Radiology at the University of Iowa, Iowa City, IA, United States
Resource Type: Journal article
Publication Details: Journal of rheumatology, Vol.41(3), pp.501-508
Publisher: Journal of Rheumatology Publishing; Toronto, ON
DOI: 10.3899/jrheum.130541
PMID: 24429179
PMCID: PMC5476295
ISSN: 0315-162X
eISSN: 1499-2752
Language: English
Date published: 2014
Academic Unit: Radiology
Record Identifier: 9984040304402771

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