Journal article
Syntheses of vinyl silane phosphates: novel synthetic intermediates
Journal of organic chemistry, Vol.54(4), pp.738-743
02/01/1989
DOI: 10.1021/jo00265a004
Abstract
A number of procedures have been developed for the synthesis of vinyl silane phosphates (VSP's), a new type of functional group bearing trialkylsilyl and diaryl (or dialkyl) phosphate groups on adjacent sp2 carbons. a-Silyl ketone enolates, accessible in a variety of ways, react with phosphorochloridates to give VSP's. Alternatively, in select cases it is possible to trap a 0-lithiated vinyl phosphate with a trialkylsilyl chloride to obtain the VSP. Because vinyl silanes are susceptible to electrophilic substitution while at least some vinyl phosphates are subject to nucleophilic substitution, a variety of applications can be envisioned for this new functional group. © 1989, American Chemical Society. All rights reserved.
Details
- Title: Subtitle
- Syntheses of vinyl silane phosphates: novel synthetic intermediates
- Creators
- Frederick L KoerwitzGerald B HammondDavid F Wiemer
- Resource Type
- Journal article
- Publication Details
- Journal of organic chemistry, Vol.54(4), pp.738-743
- Publisher
- American Chemical Society
- DOI
- 10.1021/jo00265a004
- ISSN
- 0022-3263
- eISSN
- 1520-6904
- Language
- English
- Date published
- 02/01/1989
- Academic Unit
- Chemistry; Neuroscience and Pharmacology
- Record Identifier
- 9984216577602771
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