Journal article
Synthesis and applications for unnatural sugar nucleotides
Current medicinal chemistry, Vol.6(2), pp.93-116
02/1999
PMID: 9927760
Abstract
The synthesis and biological evaluation of carbohydrate mimetics has begun to more clearly define the diverse roles of carbohydrates in nature. Often the strategy invoves the design and synthesis of glycosyltransferase and glycosidase inhibitors both as tools to elucidate the mechanism of action of these enzymes and as potential therapeutic agents. An array of unnatural sugar nucleotides have found utility in chemo-enzymatic synthesis. The regio- and stereoselective transfer of sugars by glycosyltransferases such as b1,4-galactosyltransferase, a1,3-fucosyltransferase, a2,3- and a2, 6-sialyltransferases and N-acethylglucosaminyltransferase V has demonstrated the broad application of this approach. This review summarizes the specificity of these well-studied glycosyltransferases for both unnatural sugar donors and acceptors. This information combined with the knowledge of the mechanism of action of those enzymes is valuable in the design of potent selective glycosyltransferase inhibitors and the chemo-enzymatic synthesis of novel carbohydrate mimetics.
Details
- Title: Subtitle
- Synthesis and applications for unnatural sugar nucleotides
- Creators
- J M Elhalabi - Division of Medicinal Chemistry, College of Pharmacy University of Michigan, 428 Church Street Ann Arbor MI 48109 USAK G Rice
- Resource Type
- Journal article
- Publication Details
- Current medicinal chemistry, Vol.6(2), pp.93-116
- PMID
- 9927760
- NLM abbreviation
- Curr Med Chem
- ISSN
- 0929-8673
- eISSN
- 1875-533X
- Publisher
- United Arab Emirates
- Grant note
- AI33189 / NIAID NIH HHS GM48049 / NIGMS NIH HHS
- Language
- English
- Date published
- 02/1999
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984065321502771
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