Synthesis and biological evaluation of biotinylated ZJ-101

Shan Qian; Sarah A. Head; Phillip R. Sanchez; Jun O. Liu; Zhendong Jin

doi:10.1016/j.bmcl.2023.129372

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Synthesis and biological evaluation of biotinylated ZJ-101

Journal article

Open access

Peer reviewed

Synthesis and biological evaluation of biotinylated ZJ-101

Shan Qian, Sarah A. Head, Phillip R. Sanchez, Jun O. Liu and Zhendong Jin

Bioorganic & medicinal chemistry letters, Vol.91, 129372

07/15/2023

DOI: 10.1016/j.bmcl.2023.129372

PMCID: PMC10330923

PMID: 37301523

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10330923/pdf/nihms-1907975.pdfView

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Abstract

[Display omitted] ZJ-101 is a structurally simplified analog of marine natural product superstolide A that was previously designed and synthesized in our laboratory. Biological investigation shows that ZJ-101 maintains the potent anticancer activity of the original natural product with an undefined mechanism of action. To facilitate chemical biology study, a biotinylated ZJ-101 was synthesized and biologically evaluated.

Anticancer agent

Biotinylated probe

Superstolide A

ZJ-101

Details

Title: Subtitle: Synthesis and biological evaluation of biotinylated ZJ-101
Creators: Shan Qian - University of Iowa
Sarah A. Head - Johns Hopkins Medicine
Phillip R. Sanchez - Johns Hopkins Medicine
Jun O. Liu - Johns Hopkins Medicine
Zhendong Jin - University of Iowa
Resource Type: Journal article
Publication Details: Bioorganic & medicinal chemistry letters, Vol.91, 129372
DOI: 10.1016/j.bmcl.2023.129372
PMID: 37301523
PMCID: PMC10330923
NLM abbreviation: Bioorg Med Chem Lett
ISSN: 0960-894X
eISSN: 1464-3405
Publisher: Elsevier Ltd
Language: English
Date published: 07/15/2023
Academic Unit: Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
Record Identifier: 9984433854802771

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