Journal article
Synthesis and determination of the absolute configuration of the enantiomers of modafinil
Tetrahedron: asymmetry, Vol.15(6), pp.1053-1058
03/22/2004
DOI: 10.1016/j.tetasy.2004.01.039
Abstract
Graphic
The asymmetric synthesis of both enantiomers of modafinil, a unique CNS stimulant with a reduced abuse liability, is described. This approach effectively prepares modafinil on a multigram scale in several steps from benzhydrol. The described synthetic route has also been used to produce the more water soluble analogue, adrafinil. X-ray crystallographic analysis on (−)-(diphenylmethanesulfinyl)acetic acid has determined the absolute configuration to be
R.
Details
- Title: Subtitle
- Synthesis and determination of the absolute configuration of the enantiomers of modafinil
- Creators
- Thomas Prisinzano - University of IowaJohn Podobinski - University of IowaKevin Tidgewell - University of IowaMin Luo - Division of Medicinal & Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242-1112, USADale Swenson - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Tetrahedron: asymmetry, Vol.15(6), pp.1053-1058
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.tetasy.2004.01.039
- ISSN
- 0957-4166
- eISSN
- 1362-511X
- Language
- English
- Date published
- 03/22/2004
- Academic Unit
- Chemistry
- Record Identifier
- 9984622045902771
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